Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells

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Richter, G., Hayden-Ledbetter, M., Irgang, M., Ledbetter, J.A., Westermann, J., Korner, I., Daemen, K., Clark, E.A., Aicher, A. and Pezzutto, A., 2001. Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells. Journal of Biological Chemistry, 276 (49), pp. 45686-45693. ISSN 0021-9258

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Abstract

The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and function. ICOS binds to a newly identified ligand on antigen presenting cells different from the CD152 ligands CD80 and CD86. We used soluble ICOSIg and a newly developed murine anti-human ICOS ligand (ICOSL) monoclonal antibody to further characterize the ICOSL during ontogeny of antigen presenting cells. In a previous study, we found that ICOSL is expressed on monocytes, dendritic cells, and B cells. To define when ICOSL is first expressed on myeloid antigen presenting cells, we examined ICOSL expression on CD34 cells in bone marrow. We found that CD34bright cells regardless of their myeloid commitment were ICOSL , whereas ICOSL was first expressed when CD34 expression diminished and the myeloid marker CD33 appeared.

Item Type:	Journal article
Publication Title:	Journal of Biological Chemistry
Creators:	Richter, G., Hayden-Ledbetter, M., Irgang, M., Ledbetter, J.A., Westermann, J., Korner, I., Daemen, K., Clark, E.A., Aicher, A. and Pezzutto, A.
Publisher:	American Society for Biochemistry and Molecular Biology
Date:	2001
Volume:	276
Number:	49
ISSN:	0021-9258
Rights:	© 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:16
Last Modified:	19 Oct 2015 14:29
URI:	https://irep.ntu.ac.uk/id/eprint/10299