Mammalian-wide interspersed repeats (MIRs) and their role in mammalian gene function and evolution

Croft, S.M., 2009. Mammalian-wide interspersed repeats (MIRs) and their role in mammalian gene function and evolution. PhD, Nottingham Trent University.

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Abstract

Transposable elements (TEs) are ubiquitous components of plant and animal genomes and constitute more than ~45% of the human genome. Though originally considered as 'parasitic' or 'junk' DNA, TEs are now thought to have played a role in shaping genomes during evolution, contributing to genome plasticity and diversity. All classes of retrotransposons accumulate in the genome via a process termed retrotransposition, wherein the elements are reverse transcribed into RNA and inserted into the genome as DNA. Exaptation of these elements can provide additional or novel function for endogenous genes. Mammalian-wide interspersed repeats (MIRs) are short interspersed nuclear elements (SINEs), belonging to the non-autonomous class of retroelements and are found in all mammals. The recruitment of an MIR element by a gene may provide insight into mammalian evolution and gene function.

Item Type: Thesis
Creators: Croft, S.M.
Date: 2009
Rights: This work is the intellectual property of the author, and may also be owned by the research sponsor(s) and/ or Nottingham Trent University. You may copy up to 5% of this work for private study, or personal, non-commercial research. Any re-use of the information contained within this document should be fully referenced, quoting the author, title, university, degree level and pagination. Queries or requests for any other use, or if a more substantial copy is required, should be directed in the first instance to the author.
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 09:34
Last Modified: 09 Oct 2015 09:34
URI: http://irep.ntu.ac.uk/id/eprint/104

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