Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

AICHER, A., HEESCHEN, C., SASAKI, K., URBICH, C., ZEIHER, A.M. and DIMMELER, S., 2006. Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation, 114 (25), pp. 2823-2830. ISSN 0009-7322

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Abstract

Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth factor is crucial for the recruitment of circulating endothelial progenitor cells (EPCs) during acute ischemia. In chronic ischemia, however, expression of these chemoattractants is less pronounced, which results in insufficient EPC recruitment into the target tissue. Therefore, we investigated the effect of targeted extracorporeal shock wave (SW) application in order to facilitate EPC recruitment into nonischemic and chronic ischemic tissue.

Item Type: Journal article
Publication Title: Circulation
Creators: Aicher, A., Heeschen, C., Sasaki, K., Urbich, C., Zeiher, A.M. and Dimmeler, S.
Publisher: American Heart Association
Date: 2006
Volume: 114
Number: 25
ISSN: 0009-7322
Rights: Copyright © 2006 American Heart Association. All rights reserved
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:18
Last Modified: 19 Oct 2015 14:30
URI: http://irep.ntu.ac.uk/id/eprint/10815

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