Neural endophenotypes of social behaviour in autism spectrum conditions

Lombardo, M.V., Baron-Cohen, S., Belmonte, M.K. ORCID: 0000-0002-4633-9400 and Chakrabarti, B., 2011. Neural endophenotypes of social behaviour in autism spectrum conditions. In: J. Decety and J.T. Cacioppo, eds., The Oxford handbook of social neuroscience. Oxford: Oxford University Press, pp. 830-847. ISBN 9780195342161

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Abstract

Autism is characterized by qualitative impairments in social interaction, communication, and stereotyped repetitive behaviors and/or restricted interests. Beyond these diagnostic criteria, autism is viewed as a neurodevelopmental condition with possibly several etiologies that manifest in complex patterns of atypical structural and functional brain development, cognition, and behavior. Despite the multidimensional nature of and substantial variation within the autism spectrum, impairments in social interaction remain among the most visible hallmarks of the condition. It is this profound developmental deficit in the social domain that makes autism a unique case in the field of social neuroscience. This chapter contributes to the dialogue amongst both the fields of autism research and social neuroscience by deliberately taking the stance of asking how we can understand more about the etiological mechanisms underlying social behavior in autism. It presents a multi-level overview of the literature on the behavioral, neural, and genetic underpinnings of social functioning in autism spectrum conditions (ASC). The main objective is to highlight the current state of the field regarding theory of mind/empathy difficulties in ASC, and then to suggest distinct candidate neural endophenotypes that can bridge the gap between social behavior and genetic mechanisms.

Item Type: Chapter in book
Creators: Lombardo, M.V., Baron-Cohen, S., Belmonte, M.K. and Chakrabarti, B.
Publisher: Oxford University Press
Place of Publication: Oxford
Date: 2011
Divisions: Schools > School of Social Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:21
Last Modified: 09 Jun 2017 13:27
URI: http://irep.ntu.ac.uk/id/eprint/11749

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