The topology of connections between rat prefrontal and temporal cortices

Bedwell, S.A. ORCID: 0000-0003-3283-7748, Billett, E.E. ORCID: 0000-0001-8245-6519, Crofts, J.J. ORCID: 0000-0001-7751-9984, MacDonald, D.M. and Tinsley, C.J. ORCID: 0000-0002-9369-443X, 2015. The topology of connections between rat prefrontal and temporal cortices. Frontiers in Systems Neuroscience, 9. ISSN 1662-5137

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Abstract

Understanding the structural organization of the prefrontal cortex (PFC) is an important step toward determining its functional organization. Here we investigated the organization of PFC using different neuronal tracers. We injected retrograde (Fluoro-Gold, 100 nl) and anterograde [Biotinylated dextran amine (BDA) or Fluoro-Ruby, 100 nl] tracers into sites within PFC subdivisions (prelimbic, ventral orbital, ventrolateral orbital, dorsolateral orbital) along a coronal axis within PFC. At each injection site one injection was made of the anterograde tracer and one injection was made of the retrograde tracer. The projection locations of retrogradely labeled neurons and anterogradely labeled axon terminals were then analyzed in the temporal cortex: area Te, entorhinal and perirhinal cortex. We found evidence for an ordering of both the anterograde (anterior-posterior, dorsal-ventral, and medial-lateral axes: p < 0.001) and retrograde (anterior-posterior, dorsal-ventral, and medial-lateral axes: p < 0.001) connections of PFC. We observed that anterograde and retrograde labeling in ipsilateral temporal cortex (i.e., PFC inputs and outputs) often occurred reciprocally (i.e., the same brain region, such as area 35d in perirhinal cortex, contained anterograde and retrograde labeling). However, often the same specific columnar temporal cortex regions contained only either labeling of retrograde or anterograde tracer, indicating that PFC inputs and outputs are frequently non-matched.

Item Type:	Journal article
Publication Title:	Frontiers in Systems Neuroscience
Creators:	Bedwell, S.A., Billett, E.E., Crofts, J.J., MacDonald, D.M. and Tinsley, C.J.
Publisher:	Frontiers Research Foundation
Place of Publication:	Lausanne, Switzerland
Date:	2015
Volume:	9
ISSN:	1662-5137
Identifiers:	Number Type 10.3389/fnsys.2015.00080 DOI
Rights:	© 2015 Bedwell, Billett, Crofts, MacDonald and Tinsley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:26
Last Modified:	14 Aug 2018 10:46
URI:	https://irep.ntu.ac.uk/id/eprint/12955

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