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Belmonte, M.K. 
ORCID: 0000-0002-4633-9400, Cook, E.H., Anderson, G.M., Rubenstein, J.L.R., Greenough, W.T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L.M., Powell, S.B., Levitt, P.R., Perry, E.K., Jiang, Y.H., DeLorey, T.M. and Tierney, E.,
2004.
Autism as a disorder of neural information processing: directions for research and targets for therapy.
Molecular Psychiatry, 9 (7), pp. 646-663.
ISSN 1359-4184
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Abstract
The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself.
| Item Type: | Journal article | ||||
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| Publication Title: | Molecular Psychiatry | ||||
| Creators: | Belmonte, M.K., Cook, E.H., Anderson, G.M., Rubenstein, J.L.R., Greenough, W.T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L.M., Powell, S.B., Levitt, P.R., Perry, E.K., Jiang, Y.H., DeLorey, T.M. and Tierney, E. | ||||
| Publisher: | Nature Publishing Group | ||||
| Place of Publication: | London | ||||
| Date: | 2004 | ||||
| Volume: | 9 | ||||
| Number: | 7 | ||||
| ISSN: | 1359-4184 | ||||
| Identifiers: |
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| Rights: | Copyright © 2004 by the authors listed [above]. All rights reserved. | ||||
| Divisions: | Schools > School of Social Sciences | ||||
| Record created by: | EPrints Services | ||||
| Date Added: | 09 Oct 2015 10:30 | ||||
| Last Modified: | 18 Jul 2022 14:41 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/13931 |
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