Individual variation in levels of haptoglobin-related protein in children from Gabon

Imrie, H. ORCID: 0000-0001-5214-3706, Fowkes, F.J.I., Migot-Nabias, F., Luty, J.F., Deloron, P. and Day, K.P., 2012. Individual variation in levels of haptoglobin-related protein in children from Gabon. PLoS ONE, 7 (11).

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Abstract

Background: Haptoglobin related protein (Hpr) is a key component of trypanosome lytic factors (TLF), a subset of highdensity lipoproteins (HDL) that form the first line of human defence against African trypanosomes. Hpr, like haptoglobin (Hp) can bind to hemoglobin (Hb) and it is the Hpr-Hb complexes which bind to these parasites allowing uptake of TLF. This unique form of innate immunity is primate-specific. To date, there have been no population studies of plasma levels of Hpr, particularly in relation to hemolysis and a high prevalence of ahaptoglobinemia as found in malaria endemic areas. Methods and Principal Findings: We developed a specific enzyme-linked immunosorbent assay to measure levels of plasma Hpr in Gabonese children sampled during a period of seasonal malaria transmission when acute phase responses (APR), malaria infection and associated hemolysis were prevalent. Median Hpr concentration was 0.28 mg/ml (range 0.03-1.1). This was 5-fold higher than that found in Caucasian children (0.049 mg/ml, range 0.002-0.26) with no evidence of an APR. A general linear model was used to investigate associations between Hpr levels, host polymorphisms, parasitological factors and the acute phase proteins, Hp, C-reactive protein (CRP) and albumin. Levels of Hpr were associated with Hp genotype, decreased with age and were higher in females. Hpr concentration was strongly correlated with that of Hp, but not CRP.

Item Type:	Journal article
Publication Title:	PLoS ONE
Creators:	Imrie, H., Fowkes, F.J.I., Migot-Nabias, F., Luty, J.F., Deloron, P. and Day, K.P.
Publisher:	PLoS
Date:	2012
Volume:	7
Number:	11
Identifiers:	Number Type 10.1371/journal.pone.0049816 DOI
Rights:	© 2012 Imrie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCAL), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:32
Last Modified:	09 Jun 2017 13:32
URI:	https://irep.ntu.ac.uk/id/eprint/14558

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