Escape from immunotherapy: possible mechanisms that influence tumor regression/progression

AHMAD, M., REES, R.C. and ALI, S.A., 2004. Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunology, Immunotherapy, 53 (10), pp. 844-854. ISSN 0340-7004

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Abstract

Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by the immune system under optimum conditions for activating adaptive and nonadaptive antitumor immune responses. Despite this capability, a large number of tumors continue to grow and evade recognition and/or destruction by the immune system. The limited success in current immunotherapeutic strategies may be due to a variety of reasons: failure of effector cells to compete with the growing tumor burden, production of humoral factors by tumors that locally block cytotoxicity, antigen/MHC loss, T-cell dysfunction, production of suppressor T cells—to name but a few causes for therapeutic ineffectiveness for the particular malignancy being treated. To optimize immunotherapy strategies, correction of immune-activating signals, eradication of inhibitory factors, and the evasion from newly developed immunoresistant tumor phenotypes need to be simultaneously considered.

Item Type: Journal article
Description: The original publication is available at www.springerlink.com.
Publication Title: Cancer Immunology, Immunotherapy
Creators: Ahmad, M., Rees, R.C. and Ali, S.A.
Publisher: Springer-Verlag
Place of Publication: New York
Date: 2004
Volume: 53
Number: 10
ISSN: 0340-7004
Identifiers:
NumberType
10.1007/s00262-004-0540-xDOI
Rights: © 2004 Springer, Part of Springer Science+Business Media
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:33
Last Modified: 09 Jun 2017 13:33
URI: http://irep.ntu.ac.uk/id/eprint/14678

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