Light and electron microscopical observations of the effects of high-density lipoprotein on the growth of Plasmodium falciparum in vitro

Imrie, H. ORCID: 0000-0001-5214-3706, Ferguson, D.J.P., Carter, M., Drain, J., Schiflett, A., Hajduk, S.L. and Day, K.P., 2004. Light and electron microscopical observations of the effects of high-density lipoprotein on the growth of Plasmodium falciparum in vitro. Parasitology, 128 (6), pp. 577-584.

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Abstract

Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.

Item Type:	Journal article
Publication Title:	Parasitology
Creators:	Imrie, H., Ferguson, D.J.P., Carter, M., Drain, J., Schiflett, A., Hajduk, S.L. and Day, K.P.
Publisher:	Cambridge University Press
Date:	2004
Volume:	128
Number:	6
Identifiers:	Number Type 10.1017/S0031182004005025 DOI
Rights:	© Cambridge University Press 2004
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:36
Last Modified:	09 Jun 2017 13:34
URI:	https://irep.ntu.ac.uk/id/eprint/15382

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