Light and electron microscopical observations of the effects of high-density lipoprotein on the growth of Plasmodium falciparum in vitro

IMRIE, H., FERGUSON, D.J.P., CARTER, M., DRAIN, J., SCHIFLETT, A., HAJDUK, S.L. and DAY, K.P., 2004. Light and electron microscopical observations of the effects of high-density lipoprotein on the growth of Plasmodium falciparum in vitro. Parasitology, 128 (6), pp. 577-584.

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Abstract

Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.

Item Type: Journal article
Publication Title: Parasitology
Creators: Imrie, H., Ferguson, D.J.P., Carter, M., Drain, J., Schiflett, A., Hajduk, S.L. and Day, K.P.
Publisher: Cambridge University Press
Date: 2004
Volume: 128
Number: 6
Identifiers:
NumberType
10.1017/S0031182004005025DOI
Rights: © Cambridge University Press 2004
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:36
Last Modified: 09 Jun 2017 13:34
URI: http://irep.ntu.ac.uk/id/eprint/15382

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