IMRIE, H., FERGUSON, D.J.P., CARTER, M., DRAIN, J., SCHIFLETT, A., HAJDUK, S.L. and DAY, K.P., 2004. Light and electron microscopical observations of the effects of high-density lipoprotein on the growth of Plasmodium falciparum in vitro. Parasitology, 128 (6), pp. 577-584.
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Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
|Item Type:||Journal article|
|Creators:||Imrie, H., Ferguson, D.J.P., Carter, M., Drain, J., Schiflett, A., Hajduk, S.L. and Day, K.P.|
|Publisher:||Cambridge University Press|
|Rights:||© Cambridge University Press 2004|
|Divisions:||Schools > School of Animal, Rural and Environmental Sciences|
|Depositing User:||EPrints Services|
|Date Added:||09 Oct 2015 10:36|
|Last Modified:||23 Aug 2016 09:11|
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