Beyond dopamine: functional MRI predictors of responsiveness to cognitive behaviour therapy for psychosis

KUMARI, V., ANTONOVA, E., FANNON, D., PETERS, E.R., FFYTCHE, D.H., PREMKUMAR, P., RAVEENDRAN, V., ANDREW, C., JOHNS, L.C., MCGUIRE, P.K., WILLIAMS, S.R.C. and KUIPERS, E., 2010. Beyond dopamine: functional MRI predictors of responsiveness to cognitive behaviour therapy for psychosis. Frontiers in Behavioural Neuroscience, 4.

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Abstract

Despite the favourable effects of antipsychotics on positive symptoms of schizophrenia, many patients continue to suffer from distressing symptoms. Additional benefits of cognitive behaviour therapy for psychosis (CBTp) have been reported for approximately 50% of such patients. Given the role of left hemisphere-based language processes in responsiveness to CBT for depression, and language pathway abnormalities in psychosis, this study examined whether pre-therapy brain activity during a verbal monitoring task predicts CBTp responsiveness in schizophrenia. Fifty-two outpatients, stable on antipsychotics with at least one persistent distressing positive symptom and wishing to receive CBTp adjunctive to their treatment-as-usual, and 20 healthy participants underwent fMRI during monitoring of self- and externally-generated (normal and distorted) speech. Subsequently, 26 patients received CBTp for 6–8 months adjunctive to their treatment-as-usual (CBTp + TAU, 20 completers), and 26 continued with their treatment-as-usual (TAU-alone, 18 completers). Symptoms were assessed (blindly) at entry and follow-up. The CBTp + TAU and TAU-alone groups had comparable demographic characteristics, performance and baseline symptoms.

Item Type: Journal article
Publication Title: Frontiers in Behavioural Neuroscience
Creators: Kumari, V., Antonova, E., Fannon, D., Peters, E.R., Ffytche, D.H., Premkumar, P., Raveendran, V., Andrew, C., Johns, L.C., McGuire, P.K., Williams, S.R.C. and Kuipers, E.
Publisher: Frontiers
Date: 2010
Volume: 4
Divisions: Schools > School of Social Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:37
Last Modified: 09 Jun 2017 13:34
URI: http://irep.ntu.ac.uk/id/eprint/15588

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