The topology of connections between rat prefrontal, motor and sensory cortices

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Bedwell, S.A. ORCID: 0000-0003-3283-7748, Billett, E.E. ORCID: 0000-0001-8245-6519, Crofts, J.J. ORCID: 0000-0001-7751-9984 and Tinsley, C.J. ORCID: 0000-0002-9369-443X, 2014. The topology of connections between rat prefrontal, motor and sensory cortices. Frontiers in Systems Neuroscience. ISSN 1662-5137

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Official URL: http://dx.doi.org/10.3389/fnsys.2014.00177

Abstract

The connections of prefrontal cortex (PFC) were investigated in the rat brain to determine the order and location of input and output connections to motor and somatosensory cortex. Retrograde (100 nl Fluoro-Gold) and anterograde (100 nl Biotinylated Dextran Amines, BDA; Fluorescein and Texas Red) neuronanatomical tracers were injected into the subdivisions of the PFC (prelimbic, ventral orbital, ventrolateral orbital, dorsolateral orbital) and their projections studied. We found clear evidence for organized input projections from the motor and somatosensory cortices to the PFC, with distinct areas of motor and cingulate cortex projecting in an ordered arrangement to the subdivisions of PFC. As injection location of retrograde tracer was moved from medial to lateral in PFC, we observed an ordered arrangement of projections occurring in sensory-motor cortex. There was a significant effect of retrograde injection location on the position of labelled cells occurring in sensory-motor cortex (dorsoventral, anterior-posterior and mediolateral axes p < 0.001). The arrangement of output projections from PFC also displayed a significant ordered projection to sensory-motor cortex (dorsoventral p < 0.001, anterior-posterior p = 0.002 and mediolateral axes p < 0.001).

Item Type:

Journal article

Publication Title:

Frontiers in Systems Neuroscience

Creators:

Bedwell, S.A., Billett, E.E., Crofts, J.J. and Tinsley, C.J.

Publisher:

Frontiers Media

Date:

2014

ISSN:

1662-5137