Immunotherapeutic potential of DISC-HSV and OX40L in cancer

ASSUDANI, D.P., AHMAD, M., LI, G., REES, R.C. and ALI, S.A., 2006. Immunotherapeutic potential of DISC-HSV and OX40L in cancer. Cancer Immunology Immunotherapy, 55 (1), pp. 104-111. ISSN 0340-7004

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Abstract

Several vectors, viral and bacterial, have been developed over the past few years for means of generating an effective anti-tumor immune response. We have developed and studied a “model for immunotherapy” using a viral vector DISC-HSV, which efficiently transduces various tumor cell lines and offers a useful vehicle for the further development of cell based vaccines. The immunotherapeutic potential of DISC-HSV encoding GMCSF was demonstrated in a number of murine carcinoma models, leading to complete regression of well established tumors in up to 70% of the mice. Moreover, the therapeutic potential of DISC-HSV-GMCSF was significantly enhanced when used in combination therapy with either OX40L or dendritic cells (DC), even in poorly immunogenic tumor model. The ability of this vector to accept large gene inserts, its good safety profile, its ability to undergo only a single round of infection, the inherent viral immunostimulatory properties and its ability to infect various tumor cell lines efficiently, make DISC-HSV an ideal candidate vector for immunotherapy. The DISC- CT-26 tumor model has been used to investigate these mechanisms associated with immunotherapy – induced tumor rejection. Although CTL induction, was positively correlated with regression, MHC class I down regulation and accumulation of immature Gr1+ myeloid cells were shown to be the main immuno-suppressor mechanisms operating against regression and associated with progressive tumor growth.

Item Type: Journal article
Description: The original publication is available at www.springerlink.com
Publication Title: Cancer Immunology Immunotherapy
Creators: Assudani, D.P., Ahmad, M., Li, G., Rees, R.C. and Ali, S.A.
Publisher: Springer Verlag
Place of Publication: New York
Date: 2006
Volume: 55
Number: 1
ISSN: 0340-7004
Identifiers:
NumberType
10.1007/s00262-005-0004-yDOI
Rights: © 2006 Springer Verlag
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 09:43
Last Modified: 23 Aug 2016 09:05
URI: http://irep.ntu.ac.uk/id/eprint/1758

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