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Imrie, H. 
ORCID: 0000-0001-5214-3706, Fowkes, F.J.I., Michon, P., Tavul, L., Hume, J.C.C., Piper, K.P., Reeder, J.C. and Day, K.P.,
2006.
Haptoglobin levels are associated with haptoglobin genotype and a+-thalassaemia in a malaria-endemic area.
American Journal of Tropical Medicine and Hygiene, 74 (6), pp. 965-971.
ISSN 0002-9637
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Abstract
Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites. a+-Thalassemia is a hemoglobinopathy that results in subclinical hemolytic anemia. a+-Thassemia homozygosity confers protection against severe malarial disease by an as yet unidentified mechanism. Hp levels were measured in a serial cross-sectional survey of children in Madang Province, Papua New Guinea (PNG). Hp levels were related to age, Hp genotype, Hb levels, parasitemia, splenomegaly, and ot+-thalassemia genotype. Surprisingly, children who were homozygous for a+-thalassemia had significantly higher levels of Hp than did heterozygotes, after controlling for relevant confounders. We suggest that this is the result of either reduced mean cell Hb associated with a+-thalassemia homozygosity or an elevated IL-6-dependent acute phase response.
| Item Type: | Journal article |
|---|---|
| Publication Title: | American Journal of Tropical Medicine and Hygiene |
| Creators: | Imrie, H., Fowkes, F.J.I., Michon, P., Tavul, L., Hume, J.C.C., Piper, K.P., Reeder, J.C. and Day, K.P. |
| Publisher: | The American Society of Tropical Medicine and Hygiene |
| Date: | 2006 |
| Volume: | 74 |
| Number: | 6 |
| ISSN: | 0002-9637 |
| Rights: | Copyright © 2006 by The American Society of Tropical Medicine and Hygiene |
| Divisions: | Schools > School of Animal, Rural and Environmental Sciences |
| Record created by: | EPrints Services |
| Date Added: | 09 Oct 2015 10:46 |
| Last Modified: | 09 Jun 2017 13:38 |
| URI: | https://irep.ntu.ac.uk/id/eprint/17846 |
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