Haptoglobin levels are associated with haptoglobin genotype and a+-thalassaemia in a malaria-endemic area

IMRIE, H., FOWKES, F.J.I., MICHON, P., TAVUL, L., HUME, J.C.C., PIPER, K.P., REEDER, J.C. and DAY, K.P., 2006. Haptoglobin levels are associated with haptoglobin genotype and a+-thalassaemia in a malaria-endemic area. American Journal of Tropical Medicine and Hygiene, 74 (6), pp. 965-971. ISSN 0002-9637

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Abstract

Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites. a+-Thalassemia is a hemoglobinopathy that results in subclinical hemolytic anemia. a+-Thassemia homozygosity confers protection against severe malarial disease by an as yet unidentified mechanism. Hp levels were measured in a serial cross-sectional survey of children in Madang Province, Papua New Guinea (PNG). Hp levels were related to age, Hp genotype, Hb levels, parasitemia, splenomegaly, and ot+-thalassemia genotype. Surprisingly, children who were homozygous for a+-thalassemia had significantly higher levels of Hp than did heterozygotes, after controlling for relevant confounders. We suggest that this is the result of either reduced mean cell Hb associated with a+-thalassemia homozygosity or an elevated IL-6-dependent acute phase response.

Item Type: Journal article
Publication Title: American Journal of Tropical Medicine and Hygiene
Creators: Imrie, H., Fowkes, F.J.I., Michon, P., Tavul, L., Hume, J.C.C., Piper, K.P., Reeder, J.C. and Day, K.P.
Publisher: The American Society of Tropical Medicine and Hygiene
Date: 2006
Volume: 74
Number: 6
ISSN: 0002-9637
Rights: Copyright © 2006 by The American Society of Tropical Medicine and Hygiene
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:46
Last Modified: 09 Jun 2017 13:38
URI: http://irep.ntu.ac.uk/id/eprint/17846

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