Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity

Demurtas, M. and Perry, C.C. ORCID: 0000-0003-1517-468X, 2014. Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity. Gold Bulletin, 47 (12), pp. 103-107. ISSN 2190-7579

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Abstract

Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in diverse areas such as imaging, sensing and drug vectorisation. Gold nanoparticles (GNPs) are considered a very useful platform to create a valid and efficient drug delivery/carrier system due to their facile and well-studied synthesis, easy surface functionalization and biocompatibility. In the present study, stable antibiotic conjugated GNPs were synthesised by a one-step reaction using a poorly water soluble antibiotic, amoxicillin. Amoxicillin, a member of the penicillin family, reduces the chloroauric acid to form nanoparticles and at the same time coats them to afford the functionalised nanomaterial. A range of techniques including UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) were used to ascertain the gold/drug molar ratio and the optimum temperature for synthesis of uniform monodisperse particles in the ca. 30-40 nm size range. Amoxicillin-conjugated gold showed an enhancement of antibacterial activity against Escherichia coli compared to the antibiotic alone.

Item Type: Journal article
Publication Title: Gold Bulletin
Creators: Demurtas, M. and Perry, C.C.
Publisher: Springer
Date: 2014
Volume: 47
Number: 12
ISSN: 2190-7579
Identifiers:
NumberType
10.1007/s13404-013-0129-2DOI
Rights: © Springer 2014
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:48
Last Modified: 09 Jun 2017 13:40
URI: http://irep.ntu.ac.uk/id/eprint/18533

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