The isolation and characterisation of Transglutaminase 2 inhibitors from natural sources

Aldubayan, M., 2014. The isolation and characterisation of Transglutaminase 2 inhibitors from natural sources. PhD, Nottingham Trent University.

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Abstract

Transglutaminases are calcium dependent enzymes which are involved in a variety of human disease conditions. Nine different isotypes of transglutaminases have been described including transglutaminase 2 (TG2) which is the most well characterised isotype. Transglutaminases possess a range of different catalytic activities including; the posttranslational modification of proteins by the formation of ɛ-(ƴ-glutamyl) lysine cross links between two or more proteins, the incorporation of polyamine into proteins and the deamidation of protein bound glutamine to glutamate. In coeliac disease the deamidating activity of TG2 in the intestinal lamina propria converts glutamine to glutamate in undigested gliadin peptides. This conversion elicits an immune response which causes the typical symptoms of coeliac disease. Currently the only treatment for coeliac disease is a gluten free diet. The TG2 inhibitors are the potential therapeutic agents against the coeliac disease however the current chemically synthesised TG2 inhibitors have toxicity problems. Moreover, the progress in the treatment of coeliac disease is hampered by no suitable animal model for coeliac disease and the lack of a suitable TG2 deamidation assay with which to test potential inhibitors.

Item Type: Thesis
Description: The full text of this thesis is not available due to restrictions placed by the author, use of copyrighted material, or patents pending.
Creators: Aldubayan, M.
Date: 2014
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:51
Last Modified: 09 Oct 2015 10:51
URI: http://irep.ntu.ac.uk/id/eprint/19124

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