Cytokine Modulation of Adhesion Molecule Expression on Human Retinal-Pigment Epithelial-Cells

Platts, KE, Benson, MT, Rennie, IG, Sharrard, RM and Rees, RC, 1995. Cytokine Modulation of Adhesion Molecule Expression on Human Retinal-Pigment Epithelial-Cells. Investigative Ophthalmology & Visual Science, 36 (11), pp. 2262-2269. ISSN 0146-0404

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Abstract

PURPOSE. The purpose of this study was to assess qualitatively the expression of adhesion molecules by human retinal pigment epithelium (RPE) and to study their regulation by inflammatory cytokines. These molecular events and the role played by inflammatory cytokines are important for selective lymphocyte trafficking into the eye during uveitis. METHODS. Expression of intracellular adhesion molecule-1 (ICAM- 1), endothelial leukocyte adhesion molecule-1 (ELAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), and vascular adhesion molecule (VCAM-1) by early passage human RPE cells was assessed by flow cytometry. In addition, the regulation of the expression of these molecules by the inflammatory cytokines interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha (TNF alpha), and interferon gamma (IFN gamma) was determined. Reverse transcription-polymerase chain reaction (RT-PCR) was used to characterize further adhesion molecule expression.

Item Type: Journal article
Publication Title: Investigative Ophthalmology & Visual Science
Creators: Platts, K.E., Benson, M.T., Rennie, I.G., Sharrard, R.M. and Rees, R.C.
Publisher: Association for Research in Vision and Ophthalmology
Date: 1995
Volume: 36
Number: 11
ISSN: 0146-0404
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:57
Last Modified: 19 Oct 2015 14:39
URI: http://irep.ntu.ac.uk/id/eprint/20619

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