Association of genotype with bone metabolism, skeletal adaptation and stress fracture injury occurrence

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Varley, I. ORCID: 0000-0002-3607-8921, 2014. Association of genotype with bone metabolism, skeletal adaptation and stress fracture injury occurrence. PhD, Nottingham Trent University.

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Abstract

Positive changes in bone metabolism, structural characteristics, size and mass are commonly associated with weight-bearing exercise. Despite this, negative effects of exercise on bone phenotypes, such as stress fracture injuries have been reported. Little is known about the extent of the genetic mediation of changes in bone characteristics, stress fracture injury and bone resorption in response to exercise. Accordingly, this thesis investigated: the genotype dependent changes in bone phenotypes in academy footballers before and after an increase in training volume; genetic associations with stress fracture injury in elite athletes and a preliminary investigation into genetic associations with bone resorption following 120 min of treadmill running. The tibial bone characteristics of 80, full-time academy footballers was determined using pQCT before and after 12 weeks of increased volume football training. Genetic associations with baseline, post increased training and change in bone characteristics were then determined. Secondly, radiologically confirmed stress fracture history was reported in 518 elite athletes, forming the Stress Fracture Elite Athlete (SFEA) cohort. Genetic associations were analysed for the whole group, and were also sub-stratified. Finally, recreationally active healthy male participants (n=42) performed a 120 min run at 70% O2max. Genetic associations with bone resorption at baseline, immediately, 24, 48 and 72 hours post run were investigated.

Item Type:	Thesis
Creators:	Varley, I.
Date:	2014
Rights:	This work is the intellectual property of the author. You may copy up to 5% of this work for private study, or personal, non-commercial research. Any re-use of the information contained within this document should be fully referenced, quoting the author, title, university, degree level and pagination. Queries or requests for any other use, or if a more substantial copy is required, should be directed in the owner of the Intellectual Property Rights.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:35
Last Modified:	09 Apr 2019 15:24
URI:	https://irep.ntu.ac.uk/id/eprint/223