Tools
Tools
Walton, T.J., Li, G., Seth, R., McArdle, S.E. 
ORCID: 0000-0001-6929-9782, Bishop, M.C. and Rees, R.C. ORCID: 0000-0002-4574-4746,
2008.
DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines.
DNA demethylation and histone deacetylation inhibition act synergistically to re-express oestrogen receptor beta and induce apoptosis in prostate cancer cell-lines [working title], 68 (2), pp. 210-222.
|
Text
192797_1177 Mcardle PostPrint.pdf Download (731kB) | Preview |
Abstract
Epigenetic silencing mechanisms are increasingly thought to play a major role in the development of human cancers, including prostate cancer. The two major epigenetic regulatory mechanisms involve alterations in DNA methylation and histone acetylation status. Promoter CpG island hypermethylation and histone hypoacetylation, catalysed by DNA methyltransferase (DNMT) and histone deacetylase (HDAC) respectively, are associated with transcriptional repression. Evidence in other cancers suggests the two mechanisms are dynamically linked, yet few studies have examined the potential interaction of the two pathways in prostate cancer. Here we report a synergistic, apoptotic effect of treatment with a demethylating agent and a histone deacetylase inhibitor on cultured prostate cancer cells, with associated re-expression of the putative anti-proliferative agent oestrogen receptor beta.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Description: | The definitive version is available at www3.interscience.wiley.com | ||||
| Publication Title: | DNA demethylation and histone deacetylation inhibition act synergistically to re-express oestrogen receptor beta and induce apoptosis in prostate cancer cell-lines [working title] | ||||
| Creators: | Walton, T.J., Li, G., Seth, R., McArdle, S.E., Bishop, M.C. and Rees, R.C. | ||||
| Publisher: | Wiley-Blackwell | ||||
| Date: | 2008 | ||||
| Volume: | 68 | ||||
| Number: | 2 | ||||
| Identifiers: |
|
||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | EPrints Services | ||||
| Date Added: | 09 Oct 2015 11:05 | ||||
| Last Modified: | 24 Nov 2021 14:06 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/22538 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
