DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines

Walton, T.J., Li, G., Seth, R., McArdle, S.E. ORCID: 0000-0001-6929-9782, Bishop, M.C. and Rees, R.C., 2008. DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. DNA demethylation and histone deacetylation inhibition act synergistically to re-express oestrogen receptor beta and induce apoptosis in prostate cancer cell-lines [working title], 68 (2), pp. 210-222.

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Abstract

Epigenetic silencing mechanisms are increasingly thought to play a major role in the development of human cancers, including prostate cancer. The two major epigenetic regulatory mechanisms involve alterations in DNA methylation and histone acetylation status. Promoter CpG island hypermethylation and histone hypoacetylation, catalysed by DNA methyltransferase (DNMT) and histone deacetylase (HDAC) respectively, are associated with transcriptional repression. Evidence in other cancers suggests the two mechanisms are dynamically linked, yet few studies have examined the potential interaction of the two pathways in prostate cancer. Here we report a synergistic, apoptotic effect of treatment with a demethylating agent and a histone deacetylase inhibitor on cultured prostate cancer cells, with associated re-expression of the putative anti-proliferative agent oestrogen receptor beta.

Item Type: Journal article
Description: The definitive version is available at www3.interscience.wiley.com
Publication Title: DNA demethylation and histone deacetylation inhibition act synergistically to re-express oestrogen receptor beta and induce apoptosis in prostate cancer cell-lines [working title]
Creators: Walton, T.J., Li, G., Seth, R., McArdle, S.E., Bishop, M.C. and Rees, R.C.
Publisher: Wiley-Blackwell
Date: 2008
Volume: 68
Number: 2
Identifiers:
NumberType
10.1002/pros.20673DOI
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 11:05
Last Modified: 09 Jun 2017 13:48
URI: http://irep.ntu.ac.uk/id/eprint/22538

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