Effects of organophosphates on neural and purified liver tissue transglutaminase

Muñoz, D., 2010. Effects of organophosphates on neural and purified liver tissue transglutaminase. PhD, Nottingham Trent University.

[img]
Preview
Text
213447_David Munoz Complete.pdf

Download (4MB) | Preview

Abstract

Transglutaminase 2 (TGase 2) is a multifunctional calcium dependent enzyme that catalyzes protein modifications. TGase 2 is essential in neuronal cell differentiation and it has been reported that certain organophosphates are able to inhibit this process, and the organophosphate phenyl saligenin compound also disrupts TGase 2 activity. It has also been shown that the organophosphates chlorpyrifos (CPF) and chlorpyrifos oxon (CPFO), which cause developmental neurotoxicity, provoke several changes in differentiating rat C6 glioma cells at different levels. The aims of this thesis were to analyse the effects of CPF and CPFO on the TGases present in differentiating rat C6 glioma cells, to develop a new method for the purification of TGase 2 from guinea pig liver, to study possible direct interactions between TGase 2 and esterase inhibitors and to analyze a possible pathway for the externalisation of TGase 2.

Item Type: Thesis
Creators: Muñoz, D.
Date: 2010
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 09:35
Last Modified: 09 Oct 2015 09:35
URI: http://irep.ntu.ac.uk/id/eprint/253

Actions (login required)

Edit View Edit View

Views

Views per month over past year

Downloads

Downloads per month over past year