Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

White, J.R., Winter, J.A. ORCID: 0000-0003-3582-7596 and Robinson, K., 2015. Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes. Journal of Inflammation Research, 8, pp. 137-147. ISSN 1178-7031

[img]
Preview
Text
PS_3630.pdf - Published version

Download (366kB) | Preview

Abstract

The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host-pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expression of multiple virulence factors is also often linked, making it difficult to assess the meaning of their effects in isolation. Overall, H. pylori is thought to usually modulate inflammation and limit acute damage to the mucosa, enabling the bacteria to persist. If this delicate balance is disturbed, disease may then develop.

Item Type: Journal article
Publication Title: Journal of Inflammation Research
Creators: White, J.R., Winter, J.A. and Robinson, K.
Publisher: Dove Medical Press Ltd.
Date: 13 August 2015
Volume: 8
ISSN: 1178-7031
Identifiers:
NumberType
10.2147/JIR.S64888DOI
Rights: © 2015 White et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License.
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 03 Nov 2015 09:35
Last Modified: 09 Jun 2017 13:56
URI: https://irep.ntu.ac.uk/id/eprint/26100

Actions (login required)

Edit View Edit View

Views

Views per month over past year

Downloads

Downloads per month over past year