Effect of carbohydrate feeding on the bone metabolic response to running

Sale, C ORCID: 0000-0002-5816-4169, Varley, I ORCID: 0000-0002-3607-8921, Jones, TW, James, RM ORCID: 0000-0002-7119-3159, Tang, JCY, Fraser, WD and Greeves, JP, 2015. Effect of carbohydrate feeding on the bone metabolic response to running. Journal of Applied Physiology, 119 (7), pp. 824-830. ISSN 8750-7587

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Abstract

Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses to carbohydrate (CHO) feeding during treadmill running. Ten men completed two 7-day trials, once being fed CHO (8% glucose immediately before, every 20 min during, and immediately after exercise at a rate of 0.7 g CHO·kg body mass-1·h-1) and once being fed placebo (PBO). On day 4 of each trial, participants completed a 120-min treadmill run at 70% of maximal oxygen consumption (VO2 max). Blood was taken at baseline (BASE), immediately after exercise (EE), after 60 (R1) and 120 (R2) min of recovery, and on three follow-up days (FU1-FU3). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH2-terminal propeptides of procollagen type 1 (P1NP)] were measured, along with osteocalcin (OC), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate, glucagon-like peptide-2 (GLP-2), interleukin-6 (IL-6), insulin, cortisol, leptin, and osteoprotogerin (OPG). Area under the curve was calculated in terms of the immediate (BASE, EE, R1, and R2) and short-term (BASE, FU1, FU2, and FU3) responses to exercise. β-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (β-CTX: P=0.028; P1NP: P=0.021; IL-6: P=0.036), although there was no difference in the short-term response (β-CTX: P=0.856; P1NP: P=0.721; IL-6: P=0.327). No other variable was significantly affected by CHO feeding during exercise. We conclude that CHO feeding during exercise attenuated the β-CTX and P1NP responses in the hours but not days following exercise, indicating an acute effect of CHO feeding on bone turnover.

Item Type: Journal article
Publication Title: Journal of Applied Physiology
Creators: Sale, C., Varley, I., Jones, T.W., James, R.M., Tang, J.C.Y., Fraser, W.D. and Greeves, J.P.
Publisher: The American Physiological Society
Date: 2015
Volume: 119
Number: 7
ISSN: 8750-7587
Identifiers:
NumberType
10.1152/japplphysiol.00241.2015DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 04 Nov 2015 16:23
Last Modified: 09 Jun 2017 13:56
URI: http://irep.ntu.ac.uk/id/eprint/26162

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