(In)Consistencies in responses to sodium bicarbonate supplementation: a randomised, repeated measures, counterbalanced and double-blind study

Froio de Araujo Dias, G., da Eira Silva, V., de Salles Painelli, V., Sale, C. ORCID: 0000-0002-5816-4169, Artioli, G.G. ORCID: 0000-0001-8463-2213, Gualano, B. and Saunders, B., 2015. (In)Consistencies in responses to sodium bicarbonate supplementation: a randomised, repeated measures, counterbalanced and double-blind study. PLOS ONE, 10 (11), e0143086. ISSN 1932-6203

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Abstract

Objectives:
Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. We determined the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB).
Design and Methods:
15 physically active males (age 25 ± 4 y; body mass 76.0 ± 7.3 kg; height 1.77 ± 0.05 m) completed six cycling capacity tests at 110% of maximum power output (CCT 110% ) following ingestion of either 0.3 g.kg -1 BM of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) was recorded as the exercise outcome.
Results:
SB supplementation increased blood pH, bicarbonate and base excess prior to every trial (all p ≤0.001); absolute changes in pH, bicarbonate and base excess from baseline to pre-exercise were similar in all SB trials (all p > 0.05). Blood lactate was elevated following exercise in all trials (p ≤ 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 +0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4. Individual analysis showed ten participants improved in at least one SB trial above the normal variation of the test although five improved in none.
Conclusions:
The mechanism for improved exercise with SB was consistently in place prior to exercise, although this only resulted in a likely improvement in one trial. SB does not consistently improve high intensity cycling capacity, with results suggesting that caution should be taken when interpreting the results from single trials as to the efficacy of SB supplementation.
Trial Registration:
ClinicalTrials.gov NCT02474628

Item Type:	Journal article
Publication Title:	PLOS ONE
Creators:	Froio de Araujo Dias, G., da Eira Silva, V., de Salles Painelli, V., Sale, C., Artioli, G.G., Gualano, B. and Saunders, B.
Publisher:	PLOS (Public Library of Science)
Date:	17 November 2015
Volume:	10
Number:	11
ISSN:	1932-6203
Identifiers:	Number Type 10.1371/journal.pone.0143086 DOI
Rights:	Copyright: © 2015 Froio de Araujo Dias et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Divisions:	Schools > School of Science and Technology
Record created by:	Jill Tomkinson
Date Added:	26 Nov 2015 12:04
Last Modified:	22 Sep 2017 08:15
URI:	https://irep.ntu.ac.uk/id/eprint/26514

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