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Hatziapostolou, M. 
ORCID: 0000-0003-2493-7028, Polytarchou, C. ORCID: 0000-0002-1948-7934 and Iliopoulos, D.,
2013.
miRNAs link metabolic reprogramming to oncogenesis.
Trends in Endocrinology & Metabolism, 24 (7), pp. 361-373.
ISSN 1043-2760
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PubSub4254_Polytarchou.pdf - Post-print Download (1MB) | Preview |
Abstract
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer cell proliferation and metastasis. Alterations in oncogenes and tumor suppressor genes are involved in the metabolic switch of cancer cells to aerobic glycolysis, increased glutaminolysis and fatty acid biosynthesis. MiRNAs mediate fine-tuning of genes involved directly or indirectly in cancer metabolism. In this review, we discuss the regulatory role of miRNAs on enzymes, signaling pathways and transcription factors involved in glucose and lipid metabolism. We further consider the therapeutic potential of metabolism-related miRNAs in cancer.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Trends in Endocrinology & Metabolism | ||||
| Creators: | Hatziapostolou, M., Polytarchou, C. and Iliopoulos, D. | ||||
| Publisher: | Elsevier | ||||
| Date: | 2013 | ||||
| Volume: | 24 | ||||
| Number: | 7 | ||||
| ISSN: | 1043-2760 | ||||
| Identifiers: |
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| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 03 Feb 2016 10:52 | ||||
| Last Modified: | 14 May 2018 11:04 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/26873 |
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