Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes

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Rutella, S. ORCID: 0000-0003-1970-7375 and Locatelli, F., 2012. Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes. Clinical and Developmental Immunology, 2012, p. 196063. ISSN 1740-2522

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Official URL: http://doi.org/10.1155/2012/196063

Abstract

Multiple myeloma (MM) is a plasma cell malignancy associated with high levels of monoclonal (M) protein in the blood and/or serum. MM can occur de novo or evolve from benign monoclonal gammopathy of undetermined significance (MGUS). Current translational research into MM focuses on the development of combination therapies directed against molecularly defined targets and that are aimed at achieving durable clinical responses. MM cells have a unique ability to evade immunosurveillance through several mechanisms including, among others, expansion of regulatory T cells (Treg), reduced T-cell cytotoxic activity and responsiveness to IL-2, defects in B-cell immunity, and induction of dendritic cell (DC) dysfunction. Immune defects could be a major cause of failure of the recent immunotherapy trials in MM. This article summarizes our current knowledge on the molecular determinants of immune evasion in patients with MM and highlights how these pathways can be targeted to improve patients’ clinical outcome.

Item Type:

Journal article

Publication Title:

Clinical and Developmental Immunology

Creators:

Rutella, S. and Locatelli, F.

Publisher:

Hindawi Publishing Corporation

Date:

2012

Volume:

2012