%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Suzanne Miller, Amanda P. Henry, Emily Hodge, Alexander K. Kheirallah, Charlotte K. Billington, Tracy L. Rimington, Sangita K. Bhaker, Ma’en Obeidat, Erik Melén, Simon K. Merid, Caroline Swan, Catherine Gowland, Carl P. Nelson, Ceri E. Stewart, Charlotte E. Bolton, Iain Kilty, Anders Malarstig, Stuart G. Parker, Miriam F. Moffatt, Andrew J. Wardlaw, Ian P. Hall, Ian Sayers
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref001)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref002)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref005)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref009)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref010)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref011)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref013)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref014)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref015)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref016)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref005)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref009)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0164041.ref010)>>
endobj
35 0 obj
<>/Border[0 0 0]/A 36 0 R>>
endobj
36 0 obj
<>
endobj
15 0 obj
[37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
endobj
37 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 490.9544 m
199.9998 490.9544 l
199.9998 491.4544 l
575.9997 491.4544 l
f*
0.83 0.64 0.02 0 k
317.8772 380.9197 m
322.6394 380.9197 l
h
f*
327.7417 380.9197 m
332.5606 380.9197 l
h
f*
504.3969 328.9323 m
509.2157 328.9323 l
h
f*
513.5811 328.9323 m
518.4 328.9323 l
h
f*
378.4819 289.9276 m
383.2441 289.9276 l
h
f*
387.6661 289.9276 m
392.4283 289.9276 l
h
f*
354.7843 237.9402 m
359.5465 237.9402 l
h
f*
363.9685 237.9402 m
368.7307 237.9402 l
h
f*
419.811 224.9008 m
424.5732 224.9008 l
h
f*
428.9953 224.9008 m
433.7575 224.9008 l
h
f*
438.1795 224.9008 m
447.7606 224.9008 l
h
f*
255.0614 211.9181 m
264.6425 211.9181 l
h
f*
269.8016 211.9181 m
279.3827 211.9181 l
h
f*
391.2945 185.8961 m
400.8756 185.8961 l
h
f*
381.6 159.9307 m
391.1811 159.9307 l
h
f*
533.3669 146.948 m
542.948 146.948 l
h
f*
237.1465 107.9433 m
241.9087 107.9433 l
h
f*
246.3307 107.9433 m
251.0929 107.9433 l
h
f*
255.515 107.9433 m
265.0961 107.9433 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Immunohistochem)Tj
8.1577 0 Td
(ical)Tj
1.7128 0 Td
(assessment)Tj
5.5499 0 Td
(of)Tj
1.0562 0 Td
(6)Tj
0.7699 0 Td
(adult)Tj
2.3811 0 Td
(lung)Tj
2.0946 0 Td
(samples)Tj
3.9387 0 Td
(identified)Tj
4.2012 0 Td
(high)Tj
2.1006 0 Td
(RAGE)Tj
3.0555 0 Td
(expres-)Tj
-35.0182 -1.474 Td
(sion)Tj
2.0469 0 Td
(in)Tj
0.9906 0 Td
(the)Tj
1.6053 0 Td
(alveoli)Tj
3.0375 0 Td
(of)Tj
1.0563 0 Td
(healthy)Tj
3.4314 0 Td
(adults)Tj
2.8824 0 Td
(and)Tj
1.8798 0 Td
(individuals)Tj
4.8577 0 Td
(with)Tj
1.9932 0 Td
(COPD.)Tj
/F7 1 Tf
3.3956 0 Td
(AGER)Tj
/F0 1 Tf
(/RAGE)Tj
6.1765 0 Td
(expression)Tj
-33.3532 -1.468 Td
(increased)Tj
4.5354 0 Td
(across)Tj
3.1628 0 Td
(development)Tj
5.7111 0 Td
(al)Tj
0.9906 0 Td
(stages)Tj
3.1629 0 Td
(in)Tj
0.9906 0 Td
(human)Tj
3.2643 0 Td
(fetal)Tj
2.1066 0 Td
(lung)Tj
2.1006 0 Td
(at)Tj
1.0563 0 Td
(both)Tj
2.1603 0 Td
(the)Tj
1.6053 0 Td
(mRNA)Tj
3.1628 0 Td
(\(38)Tj
1.659 0 Td
(sam-)Tj
-35.6686 -1.474 Td
(ples\))Tj
2.381 0 Td
(and)Tj
1.8739 0 Td
(protein)Tj
3.2703 0 Td
(levels)Tj
2.763 0 Td
(\(20)Tj
1.659 0 Td
(samples\).)Tj
4.5533 0 Td
(Extensive)Tj
/F7 1 Tf
4.5474 0 Td
(AGER)Tj
/F0 1 Tf
3.0554 0 Td
(splicing)Tj
3.5388 0 Td
(was)Tj
1.9932 0 Td
(identified.)Tj
4.4877 0 Td
(The)Tj
-34.123 -1.474 Td
(rs2070600T)Tj
5.5379 0 Td
(\(Ser82\))Tj
3.5508 0 Td
(allele)Tj
2.5362 0 Td
(is)Tj
0.937 0 Td
(associated)Tj
4.9889 0 Td
(with)Tj
1.9932 0 Td
(higher)Tj
2.9838 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 432.5669 631.8425 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1,)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 440.6173 633.4299 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(FEV)Tj
ET
Q
q
1 j
1 J
0 w
7.1248 0 0 6.3325 459.1559 631.8425 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 463.0677 633.4299 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(/FVC)Tj
2.5064 0 Td
(and)Tj
1.8738 0 Td
(lower)Tj
2.6019 0 Td
(serum)Tj
-34.672 -1.474 Td
(sRAGE)Tj
3.5568 0 Td
(levels)Tj
2.763 0 Td
(in)Tj
0.9966 0 Td
(UK)Tj
1.6053 0 Td
(smokers.)Tj
4.2788 0 Td
(Using)Tj
2.763 0 Td
(an)Tj
1.3308 0 Td
(airway)Tj
3.0972 0 Td
(epithelium)Tj
4.7562 0 Td
(model)Tj
2.936 0 Td
(overexpressing)Tj
6.9762 0 Td
(the)Tj
1.6113 0 Td
(Gly82)Tj
-36.6712 -1.474 Td
(or)Tj
1.104 0 Td
(Ser82)Tj
2.8824 0 Td
(variants)Tj
3.7119 0 Td
(we)Tj
1.4979 0 Td
(found)Tj
2.7093 0 Td
(that)Tj
1.8917 0 Td
(HMGB1)Tj
3.7776 0 Td
(activation)Tj
4.4339 0 Td
(of)Tj
1.0563 0 Td
(the)Tj
1.6053 0 Td
(RAGE-Ser82)Tj
6.0511 0 Td
(receptor)Tj
3.885 0 Td
(results)Tj
3.1569 0 Td
(in)Tj
-37.7633 -1.474 Td
(lower)Tj
2.596 0 Td
(sRAGE)Tj
3.5626 0 Td
(production.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 563.4708 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 546.4629 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(This)Tj
2.1065 0 Td
(study)Tj
2.6079 0 Td
(provides)Tj
3.9864 0 Td
(new)Tj
2.0469 0 Td
(information)Tj
5.1561 0 Td
(regarding)Tj
4.422 0 Td
(the)Tj
1.6113 0 Td
(expression)Tj
5.0367 0 Td
(profile)Tj
2.9301 0 Td
(and)Tj
1.8798 0 Td
(potential)Tj
3.9864 0 Td
(role)Tj
1.8798 0 Td
(of)Tj
-37.6499 -1.474 Td
(RAGE)Tj
3.0554 0 Td
(in)Tj
0.9906 0 Td
(the)Tj
1.6113 0 Td
(human)Tj
3.2643 0 Td
(lung)Tj
2.1006 0 Td
(and)Tj
1.8739 0 Td
(shows)Tj
3.0494 0 Td
(a)Tj
0.7758 0 Td
(functional)Tj
4.4817 0 Td
(role)Tj
1.8798 0 Td
(of)Tj
1.0563 0 Td
(the)Tj
1.6053 0 Td
(Gly82Ser)Tj
4.3862 0 Td
(variant.)Tj
3.4971 0 Td
(These)Tj
2.9898 0 Td
(find-)Tj
-36.6175 -1.474 Td
(ings)Tj
2.0469 0 Td
(advance)Tj
3.9863 0 Td
(our)Tj
1.6591 0 Td
(understanding)Tj
6.5286 0 Td
(of)Tj
1.0562 0 Td
(the)Tj
1.6053 0 Td
(potential)Tj
3.9864 0 Td
(mechanisms)Tj
5.8245 0 Td
(underlying)Tj
4.8099 0 Td
(COPD)Tj
3.1092 0 Td
(particularly)Tj
-34.6124 -1.474 Td
(for)Tj
1.3844 0 Td
(carriers)Tj
3.5508 0 Td
(of)Tj
1.0563 0 Td
(this)Tj
/F7 1 Tf
1.7724 0 Td
(AGER)Tj
/F0 1 Tf
3.0554 0 Td
(polymorphis)Tj
5.3769 0 Td
(m.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 438.0094 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 421.0015 cm
BT
/F8 1 Tf
1 TL
0 0 Td
[()20()1()8()]TJ
2.2733 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)2( )]TJ
3.3676 0 Td
[()1()4()6()12()2()1()1()8()]TJ
3.9968 0 Td
[()6(\r)2()13()11()2()2()]TJ
3.2541 0 Td
[()5()1( )5()-5()-10()2()-6()-5()7()8(\n)]TJ
4.6261 0 Td
[()11()-5()1()4()11()3()8()-29()]TJ
4.6318 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)]TJ
3.0047 0 Td
[()-7()9()5()]TJ
3.6 0 Td
[()13(\n)1()3()8()1()]TJ
3.0557 0 Td
[()]TJ
0.6577 0 Td
[()3()18()-5()11()]TJ
2.5852 0 Td
[()11()1()23()]TJ
-35.053 -1.2982 Td
[()2(\n)1()]TJ
1.7007 0 Td
[()6()]TJ
1.0205 0 Td
[( )-7()-9()2(\n)1()-2()]TJ
2.9423 0 Td
[()8()4()]TJ
1.7235 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[(\n)-6()-1()11()4()11()23()74()]TJ
4.0876 0 Td
[()17()]TJ
1.0998 0 Td
[()13(\n)-6()-1(\n)1()19()]TJ
2.6759 0 Td
[()8(\n)-5()8()7( )]TJ
2.2677 0 Td
[()-4(\r)4(\n)1()13(\n)]TJ
2.2507 0 Td
[(\r)3()1( )]TJ
1.5534 0 Td
[()-9(\n)-6(\n)1()]TJ
2.0976 0 Td
[( )5()5()1( )5()-6()8()19()-5()-2()-4()]TJ
4.507 0 Td
[()11()13()1()-5()13(\n)2( )5( )]TJ
3.5773 0 Td
[()1()]TJ
1.0205 0 Td
[()11()1()]TJ
-33.9928 -1.3039 Td
[()1()4()2(\n)1()7( )5()-6()8()4()1()1()8()]TJ
6.015 0 Td
[()11( )]TJ
1.0148 0 Td
[()7(\n)1()4(\n)1()-5()2()]TJ
3.0331 0 Td
[( )-1()2()-6()6()11()7( )]TJ
2.9026 0 Td
[()1( )5( )-7()-9()-2()18()6(\n)-6()]TJ
4.2406 0 Td
[(!)-3()12()-4(\r)]TJ
1.9956 0 Td
[()12()1()8()]TJ
1.9899 0 Td
[( )-7()1()4()-6()-5()2()11()]TJ
3.6 0 Td
[()-5()8()8()4(\n)1()6(\n)1()7( )]TJ
4.6601 0 Td
[()-4(\r)2()13()11()1()-6(\r)]TJ
3.4299 0 Td
[()7(\n)1()4()11()4(\n)]TJ
-32.8816 -1.2983 Td
[(!)-3()2()2(\n)]TJ
2.0976 0 Td
[()1( )5( )-7()-9()-2()18()-5()2()11()]TJ
4.6091 0 Td
[()18()11()11()13()-5()2()6(\r)4(\n)2( )]TJ
4.7338 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(#)]TJ
0.83 0.64 0.02 0 k
[($)]TJ
0 g
[(%)]TJ
2.5965 0 Td
[(&)1(\r)4(\n)1()13(\n)]TJ
2.5682 0 Td
[()3( )]TJ
0.8447 0 Td
[()]TJ
0.6577 0 Td
[(')10(\n)-9()]TJ
1.5873 0 Td
[()4(\n)-6(\n)-6()]TJ
2.1147 0 Td
[(\r)4()15(!)8(\n)-9()8(\n)1()64(\()]TJ
3.8097 0 Td
[()6()]TJ
1.0205 0 Td
[()2(\n)1( )-11()1()4(\n)]TJ
2.6702 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[()4(\n)-6()6(\r)3()8()2()3( )2()8( )]TJ
-30.7783 -1.2983 Td
[(!)-7(\r)2()2()6(\r)]TJ
2.6362 0 Td
[()1()4()2(\n)1()5()1()2(\n)]TJ
3.5149 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[()2()2(\n)1()19()-5()1( )-11()2(\n)-6()]TJ
4.0138 0 Td
[()1( )5( )-7()-9()-2()18()-5()2()11()8( )]TJ
5.1931 0 Td
[(\))26(\n)1()-6()8()3()-4()7()1( )-7(\n)2( )]TJ
5.8903 0 Td
[()11( )]TJ
1.0148 0 Td
[()7(\n)1()4()11()4(\n!)-3()2()2(\n)]TJ
5.6012 0 Td
[()1( )5( )-7()-9()-2()18()-5()2()11()]TJ
4.6092 0 Td
[( )5()10()2()1()2(\n)2( )]TJ
-33.9475 -1.3039 Td
[(*+)123(,)4(-)]TJ
3.7417 0 Td
[(\r)3()18()8(\n)]TJ
2.0692 0 Td
[()2()2(\n)1()19()-5()1( )-11()2(\n)-6()]TJ
4.0139 0 Td
[()-9()6()7()-3()4()11()-10()6(\r)2()3( )2()8( )]TJ
6.4856 0 Td
[()1()]TJ
1.0205 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[(,)26()7()1()8()4()-1(\n)-6()]TJ
4.2236 0 Td
[(*)4()7()8()-3()18()-5()2()11()]TJ
4.0988 0 Td
[(.)-1()4()]TJ
1.8482 0 Td
[()7()13()-9()12()2()-6(-)14()-9(\n)-6()1( )-11()2()]TJ
-28.9755 -1.2982 Td
[()7(\n)1()4(\n)]TJ
2.0522 0 Td
[()]TJ
/F13 1 Tf
[()35()]TJ
/F8 1 Tf
[(\()]TJ
3.2655 0 Td
[()11()7()8()11()-6()-4()]TJ
2.9537 0 Td
[(-)11(/)]TJ
1.9899 0 Td
[()1()]TJ
1.0261 0 Td
[(\n)2(0)9()11()]TJ
2.1487 0 Td
[(1)]TJ
0.6973 0 Td
[()7( 2343533)]TJ
4.3086 0 Td
[(*)4()7(62-)-15(\n)1()64(\()]TJ
4.4107 0 Td
[(7&)2()]TJ
2.5058 0 Td
[()1( )]TJ
1.0205 0 Td
[()-9(\n)1()1()8()]TJ
2.3981 0 Td
[()1( )5( )-7()-9()-2()18()6(\n)-6()]TJ
4.2463 0 Td
[(!)-3()12()-4(\r)]TJ
-33.0234 -1.2983 Td
[(8)20()11()13()-1(\n)-6()]TJ
2.9593 0 Td
[(.)-6(0)11()1()18()6()11()-29()]TJ
4.4674 0 Td
[(9)97()6()12()1()4(\n)]TJ
3.4185 0 Td
[()1()]TJ
1.0205 0 Td
[()]TJ
0.703 0 Td
[( )-7(\n)-6()-1()11()4()]TJ
2.982 0 Td
[(8.)11(9)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 376.7811 328.3086 cm
BT
/F8 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 380.4094 330.0094 cm
BT
/F8 1 Tf
1 TL
0 0 Td
[(78)20()11()13()-1(\n)-6()]TJ
3.6283 0 Td
[(9)47()12()-6()-4()]TJ
2.1713 0 Td
[()-3()18()-5()2()12()-2()]TJ
3.4696 0 Td
[(89)35()]TJ
2.7836 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
1.2642 0 Td
[(2)]TJ
0 g
[(%)]TJ
1.2643 0 Td
[(&)1(\r)4(\n)]TJ
1.7858 0 Td
[()13()6()2(\n)]TJ
1.7518 0 Td
[()11( )]TJ
/F13 1 Tf
-36.1584 -1.2982 Td
[()35()]TJ
/F8 1 Tf
2.6985 0 Td
[()4()15(!)]TJ
1.9446 0 Td
[()13(\n)-6(:)10()1()1()13(\n)2( )]TJ
3.4412 0 Td
[( )-7()1()-10()-4(\r)4(\n)1()]TJ
3.0104 0 Td
[(\n)5()12()2()2()-2()18()-5()2()11()]TJ
4.6545 0 Td
[()1()]TJ
1.0204 0 Td
[()-4(\r)4(\n)]TJ
1.4739 0 Td
[()12()1()8()]TJ
1.99 0 Td
[(!)-7(\r)2()2()6(\r)]TJ
2.6418 0 Td
[()3()18()]TJ
1.9276 0 Td
[()11()13()15()-3()2()2(\n)]TJ
3.2655 0 Td
[()4(\n)-9(!)]TJ
1.8538 0 Td
[()1()8( )2()1()-6(\r)19()]TJ
2.9424 0 Td
[()1()19()6()]TJ
1.8255 0 Td
[()-4(\r)4(\n)]TJ
-34.6901 -1.3039 Td
[()4(\n)-6()6(\r)3()8()2()3( )2()8( )]TJ
5.1817 0 Td
[()1()4()2(\n)1()5()7()-3()1()8()]TJ
4.5581 0 Td
[( )-7(\n)-9()8(\n)1()-4()]TJ
2.931 0 Td
[()12()1()8()]TJ
1.9899 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)2( )]TJ
3.3732 0 Td
[(!)-7(\r)4(\n)1()13(\n)]TJ
/F13 1 Tf
2.6247 0 Td
[()35()]TJ
/F8 1 Tf
2.7043 0 Td
[()7(\n)1()4(\n)1()-5()2()]TJ
3.033 0 Td
[()1()8()-4()-2()8()19( )]TJ
3.3902 0 Td
[(\r)3()18()8(\n)]TJ
2.0637 0 Td
[()-9(\n)-6(\n)1()]TJ
2.0976 0 Td
[()1()19()6()1()]TJ
-33.9474 -1.2983 Td
[()-3()18()6(\n)-6()6(\()]TJ
2.5341 0 Td
[()1()4()6()12()2()1()1()8()]TJ
3.9912 0 Td
[(\n)6()-3()]TJ
1.5364 0 Td
[()-7()9()5()]TJ
2.9083 0 Td
[()8()4()]TJ
1.7234 0 Td
[()12()1()8()]TJ
1.99 0 Td
[()-3()8()4()-1(\n)1()]TJ
2.8176 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(;)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
1.2641 0 Td
[(5)]TJ
0 g
[(%)]TJ
/F13 1 Tf
1.2643 0 Td
[()35()]TJ
/F8 1 Tf
2.6985 0 Td
[(\n)1()4()-1()-9()2(\n)2( )]TJ
3.4016 0 Td
[(<)-5(,)28(*.=)]TJ
3.0104 0 Td
[()]TJ
0.6633 0 Td
[()4(\n)1()10()-9(\n)1()]TJ
3.5432 0 Td
[()11( )]TJ
1.0148 0 Td
[()-4(\r)4(\n)]TJ
-34.3612 -1.2983 Td
[()1()2()19()1()4()1()-6()2()5()11()-5()1()1()]TJ
6.9505 0 Td
[( )5()12()-9(\n)1()-4( )-1()8()2()-5()7()]TJ
4.9209 0 Td
[(!)-7(\r)2()2()6(\r)]TJ
2.6362 0 Td
[()1()19()6(\n)1()2()-6( )]TJ
3.6282 0 Td
[(!)-3()12()-4(\r)]TJ
1.9899 0 Td
[()]TJ
0.652 0 Td
[()1()7()8(\n)1()7( )-7(\n)]TJ
3.0217 0 Td
[()8()8()7(\n)]TJ
2.4378 0 Td
[()11( )]TJ
1.0091 0 Td
[()1()1()2()8()4()3( \()]TJ
3.2769 0 Td
[()1()4()6()12()2()1()1()8()]TJ
3.9911 0 Td
[()-2()8()3()6()7(\n)]TJ
-34.5143 -1.3039 Td
[()1( )5( )-7()-9()-2()18()6(\n)-6()]TJ
4.2406 0 Td
[()4()6()2(\n)-6()-6()-5()-2()8()]TJ
4.1952 0 Td
[()-5()18()10()6(\n)1()-4()]TJ
3.1068 0 Td
[()11()13()11()6(\n)1()1()8( )]TJ
3.4979 0 Td
[( )5()2()6(\r)]TJ
2.0523 0 Td
[()1( )]TJ
1.0204 0 Td
[(>)17()1()-6(\r)]TJ
2.2336 0 Td
[()4()5()11()-5()1()12()-2()]TJ
3.566 0 Td
[()-5()13()11()12()]TJ
2.5908 0 Td
[()11()13()11()6(\n)1()1()]TJ
3.1295 0 Td
[(?)]TJ
1.2812 0 Td
[(>\))9(*?)]TJ
4.5468 0 Td
[(,)26()-6()-5()]TJ
-35.4611 -1.2982 Td
[()1()18()-5()2()11()]TJ
2.7212 0 Td
[()11( )]TJ
1.0148 0 Td
[(<)-5(,)28(*.)]TJ
2.795 0 Td
[(\r)3()1( )]TJ
1.5533 0 Td
[()3()8()23()]TJ
2.4718 0 Td
[()2()15(!)-3()8( )5()-5()13(\n)-5()8()]TJ
5.1591 0 Td
[(\n)1( )-11( )8(\n)-6()-6( )]TJ
2.7268 0 Td
[()1()4()6()12()2()1()1()8()]TJ
3.9911 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[()13(\n)-1()1()-5()-2()18()-5()2()11()]TJ
4.2746 0 Td
[()11( )]TJ
1.0148 0 Td
[()1()2( )-17()-2()8()2()3()18()-5()2()11(\()]TJ
5.8904 0 Td
[()-1(\n)5()-5()]TJ
-35.0869 -1.2983 Td
[()2()1()-5()18()-5()2()11(\()]TJ
4.3766 0 Td
[()11()13()6()1()1( )8(\n)1()18()-5()2()11()]TJ
5.2384 0 Td
[()8()4()]TJ
1.7178 0 Td
[()2()-5(\r)4(\n)2( )2()2()11()]TJ
3.7984 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(4)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
1.2643 0 Td
[(6)]TJ
0 g
[(%)]TJ
1.2642 0 Td
[()17()19()-9()11()-10()-6()8()19()-4()7()74(\()]TJ
5.261 0 Td
[()2()-1()-6()1()19()-5()-2()18()-5()1()8()]TJ
5.6012 0 Td
[()-2()18()-6()]TJ
1.9219 0 Td
[( )5()1()-6()7(\n)2( )5( )]TJ
3.4696 0 Td
[(<)-5(,)28(*.)]TJ
-33.9134 -1.3039 Td
[()3()18()]TJ
1.9275 0 Td
[()6()-2()18()]TJ
1.8879 0 Td
[()]TJ
0.6576 0 Td
[()13()6()2(\n)]TJ
1.7518 0 Td
[()1()]TJ
1.0262 0 Td
[()]TJ
0.6576 0 Td
[()8()8()7(\n)]TJ
2.4378 0 Td
[()11( )]TJ
1.0148 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)2( )]TJ
3.3675 0 Td
[()1()4()6()12()2()1()1()8()]TJ
3.9967 0 Td
[()-7()9()5()]TJ
2.9084 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(;)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
1.2642 0 Td
[(@)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
0.9184 0 Td
[(3)]TJ
0 g
[(%\()]TJ
1.7405 0 Td
[(,)-4(A\r)4(\n)1()1()4(\n)1()15(B)93( )]TJ
4.9663 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)6(\()]TJ
3.2201 0 Td
[()8()-10()-4(\r)2()-4()12()-5()3( )]TJ
-33.7433 -1.2983 Td
[()8()4()]TJ
1.7178 0 Td
[()1()-2()9()-9(\n)1()6(\n)2( )]TJ
3.4469 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[()]TJ
0 g
[(#)]TJ
0.83 0.64 0.02 0 k
[(1)]TJ
0 g
[(%)]TJ
3.3335 0 Td
[()8()4()]TJ
1.7234 0 Td
[( )-7()]TJ
1.0829 0 Td
[()]TJ
0.6576 0 Td
[()-5()13(\n)-5()18()6(\n)1()]TJ
2.9877 0 Td
[()1()4()2(\n)1()7( )5()-6()8()4()1()1()8()]TJ
6.015 0 Td
[()11( )]TJ
/F13 1 Tf
1.0091 0 Td
[()35()]TJ
/F8 1 Tf
2.7042 0 Td
[()13(\n)-1()1()-5()-2()18()-5()2()11()]TJ
4.2747 0 Td
[()15()]TJ
1.1792 0 Td
[()7(\n)1()4(\n)1()-5()2()]TJ
3.0387 0 Td
[()4(\n)-6()6(\r)3()]TJ
-33.1707 -1.2983 Td
[()2()3( )2()8( )]TJ
2.5625 0 Td
[(\r)3()1( )]TJ
1.559 0 Td
[()11()13()-5()2()]TJ
2.5455 0 Td
[()1()19()6()1()2()-3()18()-5()2()11()8( )]TJ
5.3688 0 Td
[(<)-5(,)28(*.)]TJ
2.795 0 Td
[()3( )]TJ
0.8447 0 Td
[(\n)2(0)11()13(\n)2( )5( )-7(\n)-6()]TJ
4.0761 0 Td
[()9()11()1()4()-2()8()19()-4()7()]TJ
4.7395 0 Td
[()1()]TJ
1.0204 0 Td
[()-4(\r)4(\n)]TJ
1.4684 0 Td
[()4(\n)1()10()11()8()4(\n)]TJ
4.5297 0 Td
[()8()4()]TJ
1.7178 0 Td
[()-18()-1()6()11()6()-2()1( )2()]TJ
-33.2274 -1.3039 Td
[()11( )]TJ
1.0091 0 Td
[()-9()11()-4(\r)]TJ
2.0579 0 Td
[()11()4(\n)1()1()4()-9()-18()-1()6(\n)2( )]TJ
5.4936 0 Td
[()8()4()]TJ
1.7234 0 Td
[()3()2()13()11()6(\r)3()6()7(\n)2( )]TJ
5.4822 0 Td
[()1()]TJ
1.0261 0 Td
[()12()1()8()]TJ
1.9898 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[($)]TJ
0 g
[(%\()]TJ
2.0863 0 Td
[( )5()1()-6()7(\n)2( )5()-5()1()8()]TJ
4.371 0 Td
[()8()]TJ
1.2019 0 Td
[()1()19()-9()11()-10()-6()8()19()]TJ
4.2633 0 Td
[()13()6()2(\n)]TJ
1.7518 0 Td
[()1()]TJ
1.0261 0 Td
[()12()1()8()]TJ
-33.4825 -1.2982 Td
[(\r)4()11()4(\n)-6()1( )5()-6()1( )2()3( )]TJ
5.2951 0 Td
[(<)-3(\n)-6()-1(\n)1()19()]TJ
2.931 0 Td
[( )5()10()2()1()2(\n)2( )]TJ
2.9763 0 Td
[()1()]TJ
1.0205 0 Td
[()-5()8()8( )-1()7(\n)1()2()2()]TJ
4.3256 0 Td
[()4()11()3( )-7(\n)]TJ
2.8402 0 Td
[()4()-9()2(\n)5()3( )]TJ
3.0841 0 Td
[(\r)3()18()8(\n)]TJ
2.0693 0 Td
[( )5(\r)4()15(!)-3()]TJ
2.8346 0 Td
[()]TJ
0.6576 0 Td
[()13()6()2(\n)]TJ
1.7518 0 Td
[( )8()11()]TJ
1.3777 0 Td
[(<)-5(,)28(*.)]TJ
2.7949 0 Td
[()1()]TJ
1.0262 0 Td
[()-4()7()8(\n)-6()]TJ
-34.9849 -1.2983 Td
[()-2()8()]TJ
1.2699 0 Td
[()4()11()-10()6(\r)4()1()7(\n)1()4(\n)2( )2()3( )]TJ
6.2815 0 Td
[()12()1()-4()1()8()]TJ
2.8857 0 Td
[()12()1()8()]TJ
1.9956 0 Td
[()2(\n)-9()8(\n)5()2()11()11()4(\n)1()19()]TJ
5.3801 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(;)]TJ
0 g
[(%)]TJ
1.8651 0 Td
[(!)-3()12()-4(\r)]TJ
1.9955 0 Td
[()15()8(\n)1()13(\n)2(0)11()13(\n)2( )5( )2()2()11()]TJ
6.1852 0 Td
[()11( )]TJ
1.0091 0 Td
[(<)-5(,)28(*.)]TJ
2.795 0 Td
[()-4()3( )-7()]TJ
1.7744 0 Td
[()-9(\n)1()1()8()]TJ
-33.4371 -1.2983 Td
[( )5(\r)4()15(!)-3()]TJ
2.8346 0 Td
[()6()]TJ
1.0261 0 Td
[()13(\n)2( )5()-5()12()]TJ
2.4378 0 Td
[()1()]TJ
1.0262 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[()2(\n)-9()8(\n)5()2()11()11()4(\n)1()19()]TJ
5.3801 0 Td
[()11( )]TJ
1.0148 0 Td
[()8()]TJ
1.2019 0 Td
[(\n)1()19()6(\r)23()1( )-7(\n)1()3()1()-5(')10(\n)]TJ
6.7633 0 Td
[()6(\r)4(\n)1()4()11()-2()-1()-9(\n)]TJ
4.4334 0 Td
[()1()]TJ
1.0261 0 Td
[()2()12()-5()12()]TJ
2.2507 0 Td
[()2()2()-1(\n)]TJ
2.126 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(5)]TJ
0 g
[(%)]TJ
-32.9893 -1.3039 Td
[()17()4()13(\n)-5()1( )-7(\n)-6()]TJ
4.0365 0 Td
[(\n)2(0)11()13(\n)2( )5( )2()2()11()]TJ
4.439 0 Td
[()11( )]TJ
1.0148 0 Td
[(<)-5(,)28(*.\()]TJ
3.0161 0 Td
[()11()]TJ
1.0828 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[( )-7()6()12()5()6()2(\n)]TJ
3.0216 0 Td
[( )8()11()-4()8( )]TJ
2.5568 0 Td
[()11( )]TJ
1.0092 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[()13(\n)-6()-1(\n)1()11()6()11()]TJ
3.5262 0 Td
[()7(\n)1()4(\n)1()18()6(\n)-6()]TJ
4.0989 0 Td
[()15()]TJ
1.1792 0 Td
[()6()2(\n)-5()18()1()6()7(\n)]TJ
-31.9291 -1.2982 Td
[( <)-5(,)28(*.)]TJ
3.8494 0 Td
[()11()]TJ
1.0828 0 Td
[()37(,)]TJ
3.0784 0 Td
[( )5()6()1()2()1()8()]TJ
3.2939 0 Td
[(\n)2( <)-5(,)28(*.\()]TJ
4.4844 0 Td
[(\r)3()1( )]TJ
1.5533 0 Td
[()-9(\n)-6(\n)1()]TJ
2.0976 0 Td
[( )8()11()1()4()]TJ
2.5965 0 Td
[()1()]TJ
1.0261 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[()8()1()-29(!)1()18()1( )]TJ
3.2259 0 Td
[()8()4()]TJ
1.7177 0 Td
[( )-7(\n)1()-10()1()]TJ
2.7043 0 Td
[()11( )]TJ
1.0091 0 Td
[()-7()9()5()]TJ
-33.1877 -1.2983 Td
[()-5()18()-5()2(\n)1()19( )]TJ
3.3675 0 Td
[(")]TJ
0.83 0.64 0.02 0 k
[(;)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
1.2643 0 Td
[(@)]TJ
0 g
[(\()]TJ
0.83 0.64 0.02 0 k
0.9184 0 Td
[(3)]TJ
0 g
[(%)]TJ
1.7404 0 Td
[(>)25()15(!)8(\n)-9()8(\n)1()64(\()]TJ
4.0366 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[()4(\n)-6()6(\r)3()8()2()3( )2()]TJ
4.8189 0 Td
[()1()4()2(\n)1()5()7()-3()1()8()]TJ
4.5579 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[()7(\n)1()4(\n)1()-5()2()]TJ
3.0331 0 Td
[()1( )5( )-7()-9()-2()18()-5()2()11()]TJ
4.6091 0 Td
[(!)-3()12()-4(\r)]TJ
1.9956 0 Td
[()12()1()8()]TJ
1.9899 0 Td
[( )-7()1()4()]TJ
-35.274 -1.3039 Td
[()-5()2()11()]TJ
1.8255 0 Td
[( )-7(\n)-6(\n)1()]TJ
1.9615 0 Td
[()18()]TJ
0.9581 0 Td
[()-4(\r)2()3( )]TJ
1.6781 0 Td
[()2()-9()-6()3( )]TJ
2.2791 0 Td
[(\r)3()1( )]TJ
1.5534 0 Td
[()1( )]TJ
1.0204 0 Td
[()8(\n)1()]TJ
1.4003 0 Td
[()4()11()]TJ
1.5647 0 Td
[()-9(\n)-6(\n)1()]TJ
2.0977 0 Td
[()2(\n)1( )-11()1()4(\n)-6()6()]TJ
3.4071 0 Td
[()17()]TJ
1.0998 0 Td
[()-4(\r)4(\n)]TJ
1.4684 0 Td
[()-6()1()-4()13(\n)1()19()]TJ
3.1521 0 Td
[( )5()10()2()7()]TJ
2.3867 0 Td
[(!)8(\n)]TJ
1.3153 0 Td
[( )-7(\n)1()]TJ
1.3039 0 Td
[()11()12()]TJ
1.5421 0 Td
[( )5()-9(\n)-6()1( )-11()2()-3()-4()-5()7()]TJ
4.5694 0 Td
[()6()]TJ
-36.5836 -1.2983 Td
[( )-7()1()-10()-4(\r)4(\n)1()]TJ
3.0104 0 Td
[()2(\n)1( )-11()1()4(\n)]TJ
2.6702 0 Td
[()-4(\r)4(\n)]TJ
1.474 0 Td
[()-9()11()6(\n)1()19()-5()-2()-4()]TJ
3.753 0 Td
[()13()6()2(\n)]TJ
1.7518 0 Td
[()11( )]TJ
/F13 1 Tf
1.0148 0 Td
[()35()]TJ
/F8 1 Tf
2.6986 0 Td
[()1()]TJ
1.0261 0 Td
[()-4(\r)4(\n)]TJ
1.4683 0 Td
[()-1()11()19()6(\n)2(0)]TJ
3.1747 0 Td
[()11( )]TJ
1.0092 0 Td
[()13(\n)2( )5()11()1()18()6()11()-29()]TJ
4.5807 0 Td
[()1()3( )-7(\n)-5()1( )-7(\n)6()]TJ
3.2202 0 Td
[(&)99()]TJ
1.3379 0 Td
[()2()]TJ
1.2416 0 Td
[()-4(\r)2()3( )]TJ
1.6781 0 Td
[(!)8(\n)]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 393.1653 745.7952 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Characte)Tj
4.0252 0 Td
(risation)Tj
3.4228 0 Td
(of)Tj
/F7 1 Tf
1.0489 0 Td
(AGER)Tj
/F0 1 Tf
(/RAG)Tj
5.2654 0 Td
(E)Tj
0.8858 0 Td
(in)Tj
0.985 0 Td
(the)Tj
1.6016 0 Td
(Human)Tj
3.4158 0 Td
(Lung)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(PLOS)Tj
2.8771 0 Td
(ONE)Tj
2.3812 0 Td
(|)Tj
0.4819 0 Td
(DOI:10.1)Tj
3.9827 0 Td
(371/journ)Tj
4.1315 0 Td
(al.pone.0164)Tj
5.7331 0 Td
(041)Tj
2.6504 0 Td
(October)Tj
3.763 0 Td
(18,)Tj
1.6016 0 Td
(2016)Tj
37.5239 0 Td
(2)Tj
0.7725 0 Td
(/)Tj
0.5031 0 Td
(16)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
68.4283 674.6457 m
111.2315 674.6457 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.025 Tc
0 0 Td
(The)Tj
1.5874 0 Td
(human)Tj
2.8134 0 Td
(embryonic)Tj
4.1598 0 Td
(and)Tj
1.5875 0 Td
(fetal)Tj
1.7716 0 Td
(material)Tj
3.1819 0 Td
(was)Tj
-15.1016 -1.3748 Td
(provided)Tj
3.4582 0 Td
(by)Tj
1.1127 0 Td
(the)Tj
1.3677 0 Td
(Joint)Tj
2.0409 0 Td
(MRC/We)Tj
3.3449 0 Td
(llcome)Tj
2.6788 0 Td
(Trust)Tj
2.1544 0 Td
(\(grant)Tj
-16.1576 -1.3748 Td
(#)Tj
0.6944 0 Td
(099175/Z/1)Tj
4.2946 0 Td
(2/Z\))Tj
1.7291 0 Td
(Human)Tj
2.9339 0 Td
(Developm)Tj
3.7418 0 Td
(ental)Tj
1.9842 0 Td
(Biology)Tj
-15.378 -1.3748 Td
(Resource)Tj
3.7488 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.hdbr)Tj
4.174 0 Td
(.org)Tj
0 g
(\).)Tj
2.2323 0 Td
(The)Tj
1.5875 0 Td
(funder)Tj
2.622 0 Td
(\(Pfizer\))Tj
-14.3646 -1.3748 Td
(provided)Tj
3.4582 0 Td
(support)Tj
3.0969 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(form)Tj
2.0126 0 Td
(of)Tj
0.9496 0 Td
(salaries)Tj
3.0189 0 Td
(for)Tj
1.2544 0 Td
(authors)Tj
-16.0442 -1.3748 Td
([IK)Tj
1.311 0 Td
(and)Tj
1.5874 0 Td
(AM],)Tj
2.0268 0 Td
(but)Tj
1.4244 0 Td
(did)Tj
1.3606 0 Td
(not)Tj
1.4174 0 Td
(have)Tj
1.963 0 Td
(any)Tj
1.5378 0 Td
(additiona)Tj
3.3733 0 Td
(l)Tj
0.411 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
-18.0284 -1.3748 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2677 0 Td
(design,)Tj
2.8985 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5875 0 Td
(analysis,)Tj
-13.656 -1.3748 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.7764 -1.3749 Td
(manuscript.)Tj
4.6417 0 Td
(The)Tj
1.5874 0 Td
(specific)Tj
3.019 0 Td
(roles)Tj
2.0338 0 Td
(of)Tj
0.9496 0 Td
(these)Tj
2.2111 0 Td
(authors)Tj
3.0473 0 Td
(are)Tj
-17.4899 -1.3748 Td
(articulated)Tj
4.0535 0 Td
(in)Tj
0.8929 0 Td
(the)Tj
1.3678 0 Td
('author)Tj
2.8134 0 Td
(contributions')Tj
5.3008 0 Td
(section.)Tj
/F9 1 Tf
-14.4284 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(AM)Tj
1.4953 0 Td
(and)Tj
1.5874 0 Td
(IK)Tj
0.9993 0 Td
(are)Tj
1.3748 0 Td
(employe)Tj
3.1535 0 Td
(es)Tj
1.063 0 Td
(of)Tj
-17.8654 -1.3748 Td
(Pfizer)Tj
2.2819 0 Td
(Ltd.)Tj
1.6441 0 Td
(PPP)Tj
1.8 0 Td
(Healthcare)Tj
4.1386 0 Td
(Medical)Tj
3.104 0 Td
(Trust)Tj
2.1472 0 Td
(funded)Tj
-15.1158 -1.3748 Td
(sample)Tj
2.9055 0 Td
(collection)Tj
3.7417 0 Td
(for)Tj
1.2544 0 Td
(SGP)Tj
1.8567 0 Td
(for)Tj
1.2543 0 Td
(this)Tj
1.5662 0 Td
(publication.)Tj
4.4859 0 Td
(AJW)Tj
-17.0647 -1.3748 Td
(is)Tj
0.8362 0 Td
(an)Tj
1.1126 0 Td
(advisory)Tj
3.352 0 Td
(board)Tj
2.374 0 Td
(member)Tj
3.3449 0 Td
(reporting)Tj
3.6001 0 Td
(personal)Tj
-14.6198 -1.3748 Td
(fees)Tj
1.7362 0 Td
(from)Tj
2.0126 0 Td
(GlaxoSmithKl)Tj
5.0174 0 Td
(ine,)Tj
1.5307 0 Td
(Boehringer)Tj
4.2874 0 Td
(Ingelheim)Tj
-14.5843 -1.3748 Td
(and)Tj
1.5874 0 Td
(Pulmocide)Tj
4.1528 0 Td
(outside)Tj
2.9267 0 Td
(of)Tj
0.9497 0 Td
(the)Tj
1.3677 0 Td
(submitted)Tj
3.9402 0 Td
(work.)Tj
2.289 0 Td
(IK)Tj
-17.2135 -1.3749 Td
(and)Tj
1.5874 0 Td
(AM's)Tj
2.1118 0 Td
(commercial)Tj
4.5851 0 Td
(affiliatio)Tj
2.8488 0 Td
(n)Tj
0.6945 0 Td
(with)Tj
1.7858 0 Td
(Pfizer)Tj
2.282 0 Td
(does)Tj
-15.8954 -1.3748 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8142 0 Td
(our)Tj
1.474 0 Td
(adherence)Tj
4.0606 0 Td
(to)Tj
0.9426 0 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8709 0 Td
(policies)Tj
3.0118 0 Td
(on)Tj
-16.93 -1.3748 Td
(sharing)Tj
2.9834 0 Td
(data)Tj
1.793 0 Td
(and)Tj
ET
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
BT
6.3638 -25.4978 Td
(materials.)Tj
ET
Q
endstream
endobj
53 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 56 0 R/Contents 57 0 R/TrimBox[0 0 612 792]>>
endobj
54 0 obj
<>
endobj
58 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
1 beginbfchar
<00EF><0394>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
59 0 obj
<>/FontDescriptor 60 0 R/DW 250/W[239[603]]>>
endobj
60 0 obj
<>
endobj
61 0 obj
<>stream
cvt f6 fpgm2Msf bglyfcW Dhead= 6hhea1 $hmtx&O