Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Santos, L.J. ORCID: 0000-0002-1915-6780, Reis, R.L. and Gomes, M.E., 2015. Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering. Trends in Biotechnology, 33 (8), pp. 471-479. ISSN 0167-7799

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Abstract

Mechanical stimulus is of upmost importance in tissues
developmental and regeneration processes as well as in
maintaining body homeostasis. Classical physiological
reactions encompass an increase of blood vessel diameter
upon exposure to high blood pressure, or the expansion
of cortical bone after continuous high-impact exercise. At a cellular level, it is well established that extracellular stiffness, topography, and remote magnetic actuation are instructive mechanical signals for stem cell differentiation. Based on this, biomaterials and their
properties can be designed to act as true stem cell
regulators, eventually leading to important advances in conventional tissue engineering techniques. This review
identifies the latest advances and tremendous potential of magnetic actuation within the scope of regenerative medicine and tissue engineering.

Item Type: Journal article
Publication Title: Trends in Biotechnology
Creators: Santos, L.J., Reis, R.L. and Gomes, M.E.
Publisher: Elsevier
Date: August 2015
Volume: 33
Number: 8
ISSN: 0167-7799
Identifiers:
NumberType
10.1016/j.tibtech.2015.06.006DOI
26123708PubMed ID
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 11 Jan 2017 11:00
Last Modified: 26 Jun 2017 03:00
URI: http://irep.ntu.ac.uk/id/eprint/29639

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