Systematic evaluation of immune regulation and modulation

Stroncek, D.F., Butterfield, L.H., Cannarile, M.A., Dhodapkar, M.V., Greten, T.F., Grivel, J.C., Kaufman, D.R., Kong, H.H., Korangy, F., Lee, P.P., Marincola, F., Rutella, S. ORCID: 0000-0003-1970-7375, Siebert, J.C., Trinchieri, G. and Seliger, B., 2017. Systematic evaluation of immune regulation and modulation. Journal for ImmunoTherapy of Cancer, 5, p. 21. ISSN 2051-1426

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Abstract

Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers.

Item Type: Journal article
Publication Title: Journal for ImmunoTherapy of Cancer
Creators: Stroncek, D.F., Butterfield, L.H., Cannarile, M.A., Dhodapkar, M.V., Greten, T.F., Grivel, J.C., Kaufman, D.R., Kong, H.H., Korangy, F., Lee, P.P., Marincola, F., Rutella, S., Siebert, J.C., Trinchieri, G. and Seliger, B.
Publisher: BioMed Central
Date: 2017
Volume: 5
ISSN: 2051-1426
Identifiers:
NumberType
10.1186/s40425-017-0223-8DOI
223Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 20 Apr 2017 08:37
Last Modified: 09 Jun 2017 14:14
URI: http://irep.ntu.ac.uk/id/eprint/30515

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