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Al-Daghri, N.M., Rahman, S., Sabico, S., Yakout, S., Wani, K., Al-Attas, O.S., Saravanan, P., Tripathi, G., McTernan, P.G. 
ORCID: 0000-0001-9023-0261 and Alokail, M.S.,
2016.
Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects.
Nutrients, 8 (9), p. 460.
ISSN 2072-6643
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Abstract
Background: This study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population. Methods: A total of 364 subjects (224 children, age: 12.99 ± 2.73 (mean ± SD) years; BMI: 20.07 ± 4.92 kg/m2 and 140 adults, age: 41.87 ± 8.82 years; BMI: 31.65 ± 5.77 kg/m2) were studied. Fasting blood, anthropometric and biochemical data were collected. Serum cytokines were quantified using multiplex assay kits and B12 concentrations were measured using immunoassay analyzer. Results: Vitamin B12 was negatively associated with TNF-α (r = −0.14, p < 0.05), insulin (r = −0.230, p < 0.01) and HOMA-IR (r = −0.252, p < 0.01) in all subjects. In children, vitamin B12 was negatively associated with serum resistin (r = −0.160, p < 0.01), insulin (r = −0.248, p < 0.01), HOMA-IR (r = −0.261, p < 0.01). In adults, vitamin B12 was negatively associated with TNF-α (r = −0.242, p < 0.01) while positively associated with resistin (r = 0.248, p < 0.01). Serum resistin was the most significant predictor for circulating vitamin B12 in all subjects (r2 = −0.17, p < 0.05) and in children (r2 = −0.167, p < 0.01) while HDL-cholesterol was the predictor of B12 in adults (r2 = −0.78, p < 0.05). Conclusions: Serum vitamin B12 concentrations were associated with pro-inflammatory cytokines and biochemical markers of cardiometabolic risks in adults. Maintaining adequate vitamin B12 concentrations may lower inflammation-induced cardiometabolic risk in the Saudi adult population.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Nutrients | ||||||
| Creators: | Al-Daghri, N.M., Rahman, S., Sabico, S., Yakout, S., Wani, K., Al-Attas, O.S., Saravanan, P., Tripathi, G., McTernan, P.G. and Alokail, M.S. | ||||||
| Publisher: | MDPI AG | ||||||
| Date: | 2016 | ||||||
| Volume: | 8 | ||||||
| Number: | 9 | ||||||
| ISSN: | 2072-6643 | ||||||
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| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 09 May 2017 09:46 | ||||||
| Last Modified: | 09 Jun 2017 14:14 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/30598 |
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