Systematic evaluation of radiological findings in the assessment of resectability of peri-ampullary cancer by CT using different contrast phase protocols

Amr, B., Miles, G., Shahtahmassebi, G. ORCID: 0000-0002-0630-2750, Roobottom, C. and Stell, D.A., 2017. Systematic evaluation of radiological findings in the assessment of resectability of peri-ampullary cancer by CT using different contrast phase protocols. Clinical Radiology. ISSN 0009-9260

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Abstract

Aims: To determine the relative significance of radiological signs in determining the resectability of peri-ampullary cancer (PC) and to assess the value of multi-phase imaging in detecting these findings.
Materials and Methods: Blinded, double re-reporting of pre-operative imaging from five hospitals was undertaken of 411 patients undergoing surgery for PC over an eight year period, of whom 119 patients were found to be inoperable at the time of surgery.
Results: The median tumour size was 26.7 mm and the proportion of patients reported to have regional lymphadenopathy (RL), venous (VI) and arterial involvement (AI) was 24.7%, 11.5% and 3.9% respectively and was similar regardless of the number of contrast phases undertaken. Significant associations were however noted between individual risk factors: VI was closely associated with tumour size (p=0.002) and AI (p< 0.0001). In multi-variable analysis AI, VI and RL were independently associated with resectability (relative risk of resection =0.05, 0.31 and 0.51 respectively). Tumour size however was not associated with resectability when VI was included in the multivariate model.

Item Type: Journal article
Publication Title: Clinical Radiology
Creators: Amr, B., Miles, G., Shahtahmassebi, G., Roobottom, C. and Stell, D.A.
Publisher: Elsevier on behalf of The Royal College of Radiologists
Date: 11 March 2017
ISSN: 0009-9260
Identifiers:
NumberType
10.1016/j.crad.2017.02.012DOI
S0009926017300776Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jill Tomkinson
Date Added: 02 Jun 2017 10:39
Last Modified: 09 Jun 2017 14:15
URI: http://irep.ntu.ac.uk/id/eprint/30841

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