T-Cell manipulation strategies to prevent graft-versus-host disease in haploidentical stem cell transplantation

Vadakekolathu, J. and Rutella, S. ORCID: 0000-0003-1970-7375, 2017. T-Cell manipulation strategies to prevent graft-versus-host disease in haploidentical stem cell transplantation. Biomedicines, 5 (2), p. 33. ISSN 2227-9059

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Abstract

Allogeneic haematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical donor can be curative for eligible patients with non-malignant and malignant haematological disorders. HSCT from alternative donor sources, such as HLA-mismatched haploidentical donors, is increasingly considered as a viable therapeutic option for patients lacking HLA-matched donors. Initial attempts at haploidentical HSCT were associated with vigorous bidirectional alloreactivity, leading to unacceptably high rates of graft rejection and graft-versus-host disease (GVHD). More recently, new approaches for mitigating harmful T-cell alloreactivity that mediates GVHD, while preserving the function of tumour-reactive natural killer (NK) cells and γδ T cells, have led to markedly improved clinical outcomes, and are successfully being implemented in the clinic. This article will provide an update on in vitro strategies and in vivo approaches aimed at preventing GVHD by selectively manipulating key components of the adaptive immune response, such as T-cell receptor (TCR)- αβ T cells and CD45RA-expressing naive T cells.

Item Type: Journal article
Publication Title: Biomedicines
Creators: Vadakekolathu, J. and Rutella, S.
Publisher: MDPI AG
Date: 2017
Volume: 5
Number: 2
ISSN: 2227-9059
Identifiers:
NumberType
10.3390/biomedicines5020033DOI
biomedicines5020033Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 22 Jun 2017 07:53
Last Modified: 07 Nov 2017 15:18
URI: http://irep.ntu.ac.uk/id/eprint/31047

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