Tools
Tools
Gillies, D., Gamal, W., Downes, A., Reinwald, Y. 
ORCID: 0000-0001-6733-605X, Yanng, Y., El Haj, A. and Bagnaninchi, P.O.,
2017.
Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.
In: K.V. Larin and D.D. Sampson, eds.,
Optical elastography and tissue biomechanics. Proceedings of SPIE, San Francisco, California, USA, 28-30 January (Vol. 10067).
Bellingham, WA: SPIE.
ISBN 9781510605756
|
Text
PubSub8766_Reinwald.pdf - Post-print Download (1MB) | Preview |
Abstract
There is an unmet need in tissue engineering for non-invasive, label-free monitoring of cell mechanical behaviour in their physiological environment. Here, we describe a novel optical coherence phase microscopy (OCPM) set-up which can map relative cell mechanical behaviour in monolayers and 3D systems non-invasively, and in real-time. 3T3 and MCF-7 cells were investigated, with MCF-7 demonstrating an increased response to hydrostatic stimulus indicating MCF-7 being softer than 3T3, demonstrating the ability to provide qualitative data on cell mechanical behaviour. Quantitative measurements of 6% agarose beads have been taken with commercial Cell Scale Microsquisher® system demonstrating that their mechanical properties are in the same order of magnitude of cells, indicating that this is an appropriate test sample for the novel method desctibed.
| Item Type: | Chapter in book | ||||
|---|---|---|---|---|---|
| Creators: | Gillies, D., Gamal, W., Downes, A., Reinwald, Y., Yanng, Y., El Haj, A. and Bagnaninchi, P.O. | ||||
| Publisher: | SPIE | ||||
| Place of Publication: | Bellingham, WA | ||||
| Date: | 21 February 2017 | ||||
| Volume: | IV | ||||
| ISBN: | 9781510605756 | ||||
| ISSN: | 0277-786X | ||||
| Identifiers: |
|
||||
| Rights: | Copyright 2017 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. | ||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 26 Jun 2017 14:09 | ||||
| Last Modified: | 10 Jul 2017 10:33 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/31097 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
