The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases?

Faulkner, S.H. ORCID: 0000-0003-4688-7252, Jackson, S., Fatania, G. and Leicht, C.A., 2017. The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases? Temperature. ISSN 2332-8940

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Abstract

Exercise and physical activity remain the gold standard methods of enhancing and maintaining health and wellbeing. However, in populations that benefit most from exercise, adherence is often poor and alternatives to exercise are important to bring about health improvements. Recent work suggests a role for passive heating (PH) and heat shock proteins (HSP) in improving cardio-metabolic health. The aim of this study was to investigate the expression of HSP70 and IL-6 in response to either exercise (EX) or PH and the subsequent effect on glucose control. Fourteen males volunteered and were categorized lean (BMI 23.5 ± 2.2 Kgm-2) or overweight (29.2 ± 2.7 Kgm-2) and completed 60 minutes of either moderate cycling at a fixed rate of metabolic heat production (EX) or warm water immersion in 40 ̊C water (PH). Extracellular HSP70 increased from baseline in both conditions with no differences between PH (0.98 ± 1.1 ngmL-1) or EX (0.84 ± 1.0 ngmL-1, P=0.814). IL-6 increased following both conditions with a 2 fold increase after PH and 4 fold after EX. Energy expenditure increased by 61.0 ± 14.4 kcal (79%) after PH. Peak glucose concentration after a meal immediately following PH was reduced when compared with EX (6.3 ± 1.4mmolL-1 vs. 6.8 ± 1.2mmolL-1; P<0.05). There was no difference in 24-hour glucose area under the curve between conditions. These data indicate the potential for thermal therapy as a novel treatment and management strategy for type 2 diabetes where adherence, or ability to exercise may be compromised.

Item Type: Journal article
Alternative Title: Passive heating, HSP70, IL-6 and energy expenditure: a treatment tool for metabolic diseases?
Passive heating - a treatment tool for metabolic diseases? [running head]
Publication Title: Temperature
Creators: Faulkner, S.H., Jackson, S., Fatania, G. and Leicht, C.A.
Publisher: Taylor & Francis
Date: 9 March 2017
ISSN: 2332-8940
Identifiers:
NumberType
10.1080/23328940.2017.1288688DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 06 Sep 2017 10:04
Last Modified: 06 Sep 2017 10:05
URI: http://irep.ntu.ac.uk/id/eprint/31559

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