Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study

Otto, J.M., O’Doherty, A.F., Hennis, P.J. ORCID: 0000-0002-8216-998X, Cooper, J.A., Grocott, M.P.W., Snowdon, C., Carlisle, J.B., Swart, M., Richards, T. and Montgomery, H.E., 2013. Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study. Perioperative Medicine, 2, p. 18. ISSN 2047-0525

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Abstract

Background: Preoperative anaemia and low exertional oxygen uptake are both associated with greater postoperative morbidity and mortality. This study reports the association among haemoglobin concentration ([Hb]), peak oxygen uptake (VO_ 2 peak) and anaerobic threshold (AT) in elective surgical patients.
Methods: Between 1999 and 2011, preoperative [Hb] and cardiopulmonary exercise tests were recorded in 1,777 preoperative patients in four hospitals. The associations between [Hb], VO_ 2 peak and AT were analysed by linear regression and covariance.
Results: In 436 (24.5%) patients, [Hb] was <12 g dl-1 and, in 83 of these, <10 g dl-1. Both AT and VO_ 2 peak rose modestly with increasing [Hb] (r2 = 0.24, P <0.0001 and r2 = 0.30, P <0.0001, respectively). After covariate adjustment, an increase in [Hb] of one standard deviation was associated with a 6.7 to 9.7% increase in VO_ 2 peak, and a rise of 4.4 to 6.0% in AT. Haemoglobin concentration accounted for 9% and 6% of the variation in VO_ 2 peak and AT respectively.
Conclusions: To a modest extent, lower haemoglobin concentrations are independently associated with lower oxygen uptake during preoperative cardiopulmonary exercise testing. It is unknown whether this association is causative.

Item Type: Journal article
Publication Title: Perioperative Medicine
Creators: Otto, J.M., O’Doherty, A.F., Hennis, P.J., Cooper, J.A., Grocott, M.P.W., Snowdon, C., Carlisle, J.B., Swart, M., Richards, T. and Montgomery, H.E.
Publisher: BioMed Central Ltd.
Date: 13 September 2013
Volume: 2
ISSN: 2047-0525
Identifiers:
NumberType
10.1186/2047-0525-2-18DOI
2047-0525-2-18Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 26 Sep 2017 10:47
Last Modified: 26 Sep 2017 10:47
URI: http://irep.ntu.ac.uk/id/eprint/31691

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