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Dolan, E, Swinton, PA, Sale, C 
ORCID: https://orcid.org/0000-0002-5816-4169, Healy, A and O’Reilly, J,
2017.
Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis.
Nutrition Reviews.
ISSN 0029-6643
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Abstract
Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations.
Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations.
Data Sources: Three databases were searched electronically. In addition, reference lists of relevant articles were screened.
Study Selection: A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review. Data Extraction: Data were extracted from each study using a standardized form.
Results: Multilevel modeling indicated opposing relationships between BMD and adiposity: absolute adiposity correlated positively, and relative adiposity negatively, with BMD. Sex and age were the primary moderators of these relationships. Strong evidence supported a negative relationship between relative adipose mass and BMD in men (R = -0.37; 95%CI, -0.57 to -0.12) and in those aged less than 25 years (R = -0.28; 95%CI, -0.45 to -0.08).
Conclusion: To prevent bone loss in overweight and obese populations, nutrition- and exercise-based interventions that focus on a controlled reduction of adipose mass with concomitant preservation of lean mass are recommended.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Nutrition Reviews |
| Creators: | Dolan, E., Swinton, P.A., Sale, C., Healy, A. and O’Reilly, J. |
| Publisher: | Oxford University Press |
| Date: | 28 September 2017 |
| ISSN: | 0029-6643 |
| Identifiers: | Number Type 10.1093/nutrit/nux046 DOI |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Jonathan Gallacher |
| Date Added: | 02 Oct 2017 08:57 |
| Last Modified: | 28 Sep 2018 03:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/31766 |
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