Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis

Dolan, E., Swinton, P.A., Sale, C. ORCID: 0000-0002-5816-4169, Healy, A. and O’Reilly, J., 2017. Influence of adipose tissue mass on bone mass in an overweight or obese population: systematic review and meta-analysis. Nutrition Reviews. ISSN 0029-6643

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Abstract

Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations.
Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations.
Data Sources: Three databases were searched electronically. In addition, reference lists of relevant articles were screened.
Study Selection: A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review. Data Extraction: Data were extracted from each study using a standardized form.
Results: Multilevel modeling indicated opposing relationships between BMD and adiposity: absolute adiposity correlated positively, and relative adiposity negatively, with BMD. Sex and age were the primary moderators of these relationships. Strong evidence supported a negative relationship between relative adipose mass and BMD in men (R = -0.37; 95%CI, -0.57 to -0.12) and in those aged less than 25 years (R = -0.28; 95%CI, -0.45 to -0.08).
Conclusion: To prevent bone loss in overweight and obese populations, nutrition- and exercise-based interventions that focus on a controlled reduction of adipose mass with concomitant preservation of lean mass are recommended.

Item Type: Journal article
Publication Title: Nutrition Reviews
Creators: Dolan, E., Swinton, P.A., Sale, C., Healy, A. and O’Reilly, J.
Publisher: Oxford University Press
Date: 28 September 2017
ISSN: 0029-6643
Identifiers:
NumberType
10.1093/nutrit/nux046DOI
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 02 Oct 2017 08:57
Last Modified: 02 Oct 2017 08:58
URI: http://irep.ntu.ac.uk/id/eprint/31766

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