Tools
Tools
Edkins, A.L., Price, J.T., Pockley, A.G. 
ORCID: 0000-0001-9593-6431 and Blatch, G.L.,
2018.
Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective.
Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1738), p. 20160522.
ISSN 0962-8436
|
Text
9677_Pockley.pdf - Post-print Download (230kB) | Preview |
Abstract
Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguably among the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a number of different diseases. Although the concept was initially controversial, it is now widely accepted that HSPs have additional biological functions over and above their role in proteostasis (so-called ‘protein moonlighting’). Most importantly, these new insights are enlightening our understanding of biological processes in health and disease, and revealing novel and exciting therapeutic opportunities. This theme issue draws on therapeutic insights from established research on HSPs in cancer and other non-communicable disorders, with an emphasis on how the intracellular function of HSPs contrasts with their extracellular properties and function, and interrogates their potential diagnostic and therapeutic value to the prevention, management and treatment of chronic diseases.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Philosophical Transactions of the Royal Society B: Biological Sciences | ||||||
| Creators: | Edkins, A.L., Price, J.T., Pockley, A.G. and Blatch, G.L. | ||||||
| Publisher: | The Royal Society | ||||||
| Date: | 19 January 2018 | ||||||
| Volume: | 373 | ||||||
| Number: | 1738 | ||||||
| ISSN: | 0962-8436 | ||||||
| Identifiers: |
|
||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 07 Dec 2017 16:33 | ||||||
| Last Modified: | 17 Jan 2018 12:21 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/32171 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
