Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective

Edkins, A.L., Price, J.T., Pockley, A.G. ORCID: 0000-0001-9593-6431 and Blatch, G.L., 2017. Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1738), p. 20160522. ISSN 0962-8436

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Abstract

Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguably among the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a number of different diseases. Although the concept was initially controversial, it is now widely accepted that HSPs have additional biological functions over and above their role in proteostasis (so-called ‘protein moonlighting’). Most importantly, these new insights are enlightening our understanding of biological processes in health and disease, and revealing novel and exciting therapeutic opportunities. This theme issue draws on therapeutic insights from established research on HSPs in cancer and other non-communicable disorders, with an emphasis on how the intracellular function of HSPs contrasts with their extracellular properties and function, and interrogates their potential diagnostic and therapeutic value to the prevention, management and treatment of chronic diseases.

Item Type: Journal article
Publication Title: Philosophical Transactions of the Royal Society B: Biological Sciences
Creators: Edkins, A.L., Price, J.T., Pockley, A.G. and Blatch, G.L.
Publisher: The Royal Society
Date: 4 December 2017
Volume: 373
Number: 1738
ISSN: 0962-8436
Identifiers:
NumberType
10.1098/rstb.2016.0521DOI
29203706PubMed ID
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 07 Dec 2017 16:33
Last Modified: 07 Dec 2017 16:34
URI: http://irep.ntu.ac.uk/id/eprint/32171

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