Maximum human objectively measured pharmacologically stimulated accommodative amplitude

Grzybowski, A., Schachar, R.A., Gaca-Wysocka, M., Schachar, I.H. and Pierscionek, B.K. ORCID: 0000-0002-8661-6353, 2018. Maximum human objectively measured pharmacologically stimulated accommodative amplitude. Clinical Ophthalmology, 12, pp. 201-205. ISSN 1177-5467

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Abstract

Purpose: To measure the maximum, objectively measured, accommodative amplitude, produced by pharmacologic stimulation.
Methods: Thirty-seven healthy subjects were enrolled, with a mean age of 20.2±1.1 years, corrected visual acuity of 20/20, and mean spherical equivalent refraction (SER) =–0.83±1.60 diopters. For each subject, the right pupil was dilated with phenylephrine 10%. After 30 minutes, the pupil was measured, the left eye was patched, and the right eye was autorefracted. Pilocarpine 4% was then instilled in the right eye, followed by phenylephrine. At 45 minutes after the pilocarpine, autorefraction and pupil size were again measured.
Results: Mean pupil size pre- and postpilocarpine was 8.0±0.8 mm and 4.4±1.9 mm, respectively. Pre- and postpilocarpine, the mean SER was –0.83±1.60 and –10.55±4.26 diopters, respectively. The mean pilocarpine-induced accommodative amplitude was 9.73±3.64 diopters. Five subjects had accommodative amplitudes ≥14.00 diopters. Accommodative amplitude was not significantly related to baseline SER (p-value =0.24), pre- or postpilocarpine pupil size (p-values =0.13 and 0.74), or change in pupil size (p-value =0.37). Iris color did not statistically significantly affect accommodative amplitude (p-value =0.83).
Conclusion: Following topically applied pilocarpine, the induced objectively measured accommodation in the young eye is greater than or equal to the reported subjectively measured voluntary maximum accommodative amplitude.

Item Type: Journal article
Publication Title: Clinical Ophthalmology
Creators: Grzybowski, A., Schachar, R.A., Gaca-Wysocka, M., Schachar, I.H. and Pierscionek, B.K.
Publisher: DovePress
Date: 2018
Volume: 12
ISSN: 1177-5467
Identifiers:
NumberType
10.2147/OPTH.S154432DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 24 Jan 2018 12:06
Last Modified: 24 Jan 2018 12:06
URI: http://irep.ntu.ac.uk/id/eprint/32531

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