Emulation of chemical stimulus triggered head movement in the C. elegans nematode

Costalago-Meruelo, A., Machado, P. ORCID: 0000-0003-1760-3871, Appiah, K. ORCID: 0000-0002-9480-0679, Mujika, A., Leskovsky, P., Alvarez, R., Epelde, G. and McGinnity, T.M. ORCID: 0000-0002-9897-4748, 2018. Emulation of chemical stimulus triggered head movement in the C. elegans nematode. Neurocomputing. ISSN 0925-2312

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Abstract

For a considerable time, it has been the goal of computational neuroscientists to understand biological nervous systems. However, the vast complexity of such systems has made it very difficult to fully understand even basic functions such as movement. Because of its small neuron count, the C. elegans nematode offers the opportunity to study a fully described connectome and attempt to link neural network activity to behaviour. In this paper a simulation of the neural network in C. elegans that responds to chemical stimulus is presented and a consequent realistic head movement demonstrated. An evolutionary algorithm (EA) has been utilised to search for estimates of the values of the synaptic conductances and also to determine whether each synapse is excitatory or inhibitory in nature. The chemotaxis neural network was designed and implemented, using the parameterization obtained with the EA, on the Si elegans platform a state-of-the-art hardware emulation platform specially designed to emulate the C. elegans nematode.

Item Type: Journal article
Publication Title: Neurocomputing
Creators: Costalago-Meruelo, A., Machado, P., Appiah, K., Mujika, A., Leskovsky, P., Alvarez, R., Epelde, G. and McGinnity, T.M.
Publisher: Elsevier
Date: 15 February 2018
ISSN: 0925-2312
Identifiers:
NumberType
10.1016/j.neucom.2018.02.024DOI
S0925231218301590Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 22 Feb 2018 10:00
Last Modified: 26 Feb 2018 12:00
URI: http://irep.ntu.ac.uk/id/eprint/32781

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