Targeting leukemia stem cells in the bone marrow niche

Tasian, S.K., Bornhäuser, M. and Rutella, S. ORCID: 0000-0003-1970-7375, 2018. Targeting leukemia stem cells in the bone marrow niche. Biomedicines, 6 (1): 22. ISSN 2227-9059

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Abstract

The bone marrow (BM) niche encompasses multiple cells of mesenchymal and hematopoietic origin and represents a unique microenvironment that is poised to maintain hematopoietic stem cells. In addition to its role as a primary lymphoid organ through the support of lymphoid development, the BM hosts various mature lymphoid cell types, including naïve T cells, memory T cells and plasma cells, as well as mature myeloid elements such as monocyte/macrophages and neutrophils, all of which are crucially important to control leukemia initiation and progression. The BM niche provides an attractive milieu for tumor cell colonization given its ability to provide signals which accelerate tumor cell proliferation and facilitate tumor cell survival. Cancer stem cells (CSCs) share phenotypic and functional features with normal counterparts from the tissue of origin of the tumor and can self-renew, differentiate and initiate tumor formation. CSCs possess a distinct immunological profile compared with the bulk population of tumor cells and have evolved complex strategies to suppress immune responses through multiple mechanisms, including the release of soluble factors and the over-expression of molecules implicated in cancer immune evasion. This chapter discusses the latest advancements in understanding of the immunological BM niche and highlights current and future immunotherapeutic strategies to target leukemia CSCs and overcome therapeutic resistance in the clinic.

Item Type: Journal article
Publication Title: Biomedicines
Creators: Tasian, S.K., Bornhäuser, M. and Rutella, S.
Publisher: MDPI AG
Date: March 2018
Volume: 6
Number: 1
ISSN: 2227-9059
Identifiers:
NumberType
10.3390/biomedicines6010022DOI
biomedicines6010022Publisher Item Identifier
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Science and Technology
Depositing User: Jill Tomkinson
Date Added: 05 Mar 2018 12:11
Last Modified: 05 Mar 2018 12:11
URI: http://irep.ntu.ac.uk/id/eprint/32847

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