A level set approach to segmenting a deforming myocardium from dynamically acquired SPECT projection data

Neacsu, F., Boutchko, R., Giannakidis, A. ORCID: 0000-0001-7403-923X and Gullberg, G.T., 2010. A level set approach to segmenting a deforming myocardium from dynamically acquired SPECT projection data. In: 2010 IEEE Nuclear Science Symposium & Medical Imaging Conference Record (NSS/MIC 2010). Piscataway, NJ: Institute of Electrical and Electronics Engineers, pp. 3588-3592. ISBN 9781424491056

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Abstract

Dynamic cardiac single photon emission computed tomography (SPECT) offers an effective way for observing fundamental physiological functions of organs and could aid in the early diagnosis of cardiovascular disease, in particular, for those patients with minimal disease. This would improve the chances of recovery by initiating appropriate therapy and an altered life style. To make dynamic cardiac SPECT viable with present clinical scanners methods need to be developed that reconstruct time activity curves from dynamically moving organs representing the change of tracer concentration as a function of time from projection data acquired from slowly rotating gamma cameras. This type of data analysis faces the challenge of modeling both rigid and non-rigid body deformation as well as modeling of a time varying tracer concentration. In the work presented here, we develop methods for segmenting the beating heart using an approach based upon level sets, which can deal naturally with topological changes. A variational formulation of the level set method was implemented. This allowed the inclusion of a priori information and was computationally efficient. The algorithm was first evaluated with simulated dynamic cardiac image data. The MCAT phantom was used to generate data containing 32 time frames over one cardiac cycle. Each frame had a matrix size of 64×64×32 voxels with a resolution of 6.25 mm. Starting with an initial estimate of the boundary, the algorithm then converged to an accurate segmentation of the deforming heart. The initial estimate was not important and we could segment simultaneously both interior and exterior boundaries. This algorithm forms the foundation for the segmentation of the boundary of the deforming myocardium directly from projection data.

Item Type: Chapter in book
Description: Proceedings of the 2010 IEEE Nuclear Science Symposium & Medical Imaging Conference (NSS/MIC 2010), Knoxville, Tennessee, United States, October - 6 November 2010.
Creators: Neacsu, F., Boutchko, R., Giannakidis, A. and Gullberg, G.T.
Publisher: Institute of Electrical and Electronics Engineers
Place of Publication: Piscataway, NJ
Date: 2010
Identifiers:
NumberType
10.1109/NSSMIC.2010.5874479DOI
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 28 Mar 2018 10:51
Last Modified: 28 Mar 2018 10:51
URI: http://irep.ntu.ac.uk/id/eprint/33132

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