Diffusion tensor magnetic resonance imaging-derived myocardial fiber disarray in hypertensive left ventricular hypertrophy: visualization, quantification and the effect on mechanical function

Giannakidis, A. ORCID: 0000-0001-7403-923X, Rohmer, D., Veress, A.I. and Gullberg, G.T., 2013. Diffusion tensor magnetic resonance imaging-derived myocardial fiber disarray in hypertensive left ventricular hypertrophy: visualization, quantification and the effect on mechanical function. In: M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M.E. Josephson, eds., Cardiac mapping. 4th ed. Oxford: Wiley-Blackwell, pp. 574-588. ISBN 9780470670460

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Abstract

Left ventricular hypertrophy induced by systemic hypertension is generally regarded a morphological precursor of unfortunate cardiovascular events. Myocardial fiber disarray has been long recognized as a prevalent hallmark of this pathology. In this chapter, ex vivo diffusion tensor magnetic resonance imaging is employed to delineate the regional loss of myocardial organization that is present in the excised heart of a spontaneously hypertensive rat, as opposed to a control. Fiber tracking results are provided that illustrate in great detail the alterations in the integrity of cardiac muscle microstructure due to the disease. A quantitative analysis is also performed. Another contribution of this chapter is the model-based assessment of the role of the myofiber disarray in modulating the mechanical properties of the myocardium. The results of this study improve our understanding of the structural remodeling mechanisms that are associated with hypetensive left ventricular hypertrophy and their role.

Item Type: Chapter in book
Creators: Giannakidis, A., Rohmer, D., Veress, A.I. and Gullberg, G.T.
Publisher: Wiley-Blackwell
Place of Publication: Oxford
Date: 2013
Identifiers:
NumberType
10.1002/9781118481585.ch53DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 04 Apr 2018 08:22
Last Modified: 05 Apr 2018 07:05
URI: http://irep.ntu.ac.uk/id/eprint/33162

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