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Adaikalakoteswari, A. 
ORCID: 0000-0003-2974-3388, Rabbani, N., Waspadji, S., Tjokroprawiro, A., Kariadi, S.H.K.S., Adam, J.M.F. and Thornalley, P.J.,
2012.
Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia - link to renal status, glycemic control and vascular inflammation.
Diabetes Research and Clinical Practice, 95 (3), pp. 415-424.
ISSN 0168-8227
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Abstract
Background: Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia.
Methods: One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B1, B6, B9 and B12, were determined.
Results: Fractional excretion of thiamine (22.8 versus 33.5%; P < 0.05) and urinary excretion of the vitamin B6 degradation product 4-pyridoxic acid (0.081 versus 0.133 μmol/g creatinine, P < 0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547 pmol/l, P < 0.001) and holotranscobalamin (74 versus 97 pmol/l, P < 0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively.
Conclusions: There was renal mishandling of thiamine, increased degradation of vitamin B6 and cytosolic metabolic resistance to vitamin B12 in patients with type 2 diabetes in Indonesia.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Diabetes Research and Clinical Practice | ||||||
| Creators: | Adaikalakoteswari, A., Rabbani, N., Waspadji, S., Tjokroprawiro, A., Kariadi, S.H.K.S., Adam, J.M.F. and Thornalley, P.J. | ||||||
| Publisher: | Elsevier Ireland | ||||||
| Date: | April 2012 | ||||||
| Volume: | 95 | ||||||
| Number: | 3 | ||||||
| ISSN: | 0168-8227 | ||||||
| Identifiers: |
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| Rights: | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 04 May 2018 10:31 | ||||||
| Last Modified: | 04 May 2018 10:31 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/33440 |
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