Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia - link to renal status, glycemic control and vascular inflammation

Adaikalakoteswari, A. ORCID: 0000-0003-2974-3388, Rabbani, N., Waspadji, S., Tjokroprawiro, A., Kariadi, S.H.K.S., Adam, J.M.F. and Thornalley, P.J., 2012. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia - link to renal status, glycemic control and vascular inflammation. Diabetes Research and Clinical Practice, 95 (3), pp. 415-424. ISSN 0168-8227

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Abstract

Background: Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia.

Methods: One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B1, B6, B9 and B12, were determined.

Results: Fractional excretion of thiamine (22.8 versus 33.5%; P < 0.05) and urinary excretion of the vitamin B6 degradation product 4-pyridoxic acid (0.081 versus 0.133 μmol/g creatinine, P < 0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547 pmol/l, P < 0.001) and holotranscobalamin (74 versus 97 pmol/l, P < 0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively.

Conclusions: There was renal mishandling of thiamine, increased degradation of vitamin B6 and cytosolic metabolic resistance to vitamin B12 in patients with type 2 diabetes in Indonesia.

Item Type: Journal article
Publication Title: Diabetes Research and Clinical Practice
Creators: Adaikalakoteswari, A., Rabbani, N., Waspadji, S., Tjokroprawiro, A., Kariadi, S.H.K.S., Adam, J.M.F. and Thornalley, P.J.
Publisher: Elsevier Ireland
Date: April 2012
Volume: 95
Number: 3
ISSN: 0168-8227
Identifiers:
NumberType
10.1016/j.diabres.2011.10.042DOI
S016882271100605XPublisher Item Identifier
Rights: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 04 May 2018 10:31
Last Modified: 04 May 2018 10:31
URI: http://irep.ntu.ac.uk/id/eprint/33440

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