Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis

Kihm, L.P., Müller-Krebs, S., Klein, J., Ehrlich, G., Mertes, L., Gross, M.-L., Adaikalakoteswari, A. ORCID: 0000-0003-2974-3388, Thornalley, P.J., Hammes, H.-P., Nawroth, P.P., Zeier, M. and Schwenger, V., 2011. Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. Journal of the American Society of Nephrology, 22 (5), pp. 914-926. ISSN 1046-6673

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Abstract

Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum. Benfotiamine decreases glucose-induced tissue damage, suggesting the potential for benefit in peritoneal dialysis. Here, in a model of peritoneal dialysis in uremic rats, treatment with benfotiamine decreased peritoneal fibrosis, markers of inflammation, and neovascularization, resulting in improved characteristics of peritoneal transport. Furthermore, rats treated with benfotiamine exhibited lower expression of advanced glycation endproducts and their receptor in the peritoneum and the kidney, reduced glomerular and tubulointerstitial damage, and less albuminuria. Increased activity of transketolase in tissue and blood contributed to the protective effects of benfotiamine. In primary human peritoneal mesothelial cells, the addition of benfotiamine led to enhanced transketolase activity and decreased expression of advanced glycation endproducts and their receptor. Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia.

Item Type: Journal article
Publication Title: Journal of the American Society of Nephrology
Creators: Kihm, L.P., Müller-Krebs, S., Klein, J., Ehrlich, G., Mertes, L., Gross, M.-L., Adaikalakoteswari, A., Thornalley, P.J., Hammes, H.-P., Nawroth, P.P., Zeier, M. and Schwenger, V.
Publisher: American Society of Nephrology
Date: 2011
Volume: 22
Number: 5
ISSN: 1046-6673
Identifiers:
NumberType
10.1681/ASN.2010070750DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 04 May 2018 10:57
Last Modified: 04 May 2018 10:57
URI: http://irep.ntu.ac.uk/id/eprint/33441

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