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Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Shinada, T., Sakaki, K., Sassa, Y., Nozawa, T., Ikeda, S., Yokota, S., Magistro, D. 
ORCID: 0000-0002-2554-3701 and Kawashima, R.,
2018.
Refractive error is associated with intracranial volume.
Scientific Reports, 8: 175.
ISSN 2045-2322
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PubSub10983_Magistro.pdf - Published version Download (1MB) | Preview |
Abstract
Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a signifcant negative correlation with total intracranial volume and total cerebrospinal fuid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
| Item Type: | Journal article | ||||||
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| Publication Title: | Scientific Reports | ||||||
| Creators: | Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Shinada, T., Sakaki, K., Sassa, Y., Nozawa, T., Ikeda, S., Yokota, S., Magistro, D. and Kawashima, R. | ||||||
| Publisher: | Springer Nature | ||||||
| Date: | 9 January 2018 | ||||||
| Volume: | 8 | ||||||
| ISSN: | 2045-2322 | ||||||
| Identifiers: |
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| Rights: | Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2017. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jill Tomkinson | ||||||
| Date Added: | 08 May 2018 14:02 | ||||||
| Last Modified: | 08 May 2018 14:02 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/33457 |
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