Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients

Martin, S.G., Lebot, M.N., Sukkarn, B., Ball, G. ORCID: 0000-0001-5828-7129, Green, A.R., Rakha, E.A., Ellis, I.O. and Storr, S.J., 2018. Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients. Oncotarget, 9 (40), pp. 25946-25956. ISSN 1949-2553

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Abstract

G protein-coupled oestrogen receptor 1 (GPER), also called G protein-coupled receptor 30 (GPR30), is attracting considerable attention for its potential role in breast cancer development and progression. Activation by oestrogen (17β-oestradiol; E2) initiates short term, non-genomic, signalling events both in vitro and in vivo. Published literature on the prognostic value of GPER protein expression in breast cancer indicates that further assessment is warranted. We show, using immunohistochemistry on a large cohort of primary invasive breast cancer patients (n=1245), that low protein expression of GPER is not only significantly associated with clinicopathological and molecular features of aggressive behaviour but also significantly associated with adverse survival of breast cancer patients. Furthermore, assessment of GPER mRNA levels in the METABRIC cohort (n=1980) demonstrates that low GPER mRNA expression is significantly associated with adverse survival of breast cancer patients. Using artificial neural networks, genes associated with GPER mRNA expression were identified; these included notch-4 and jagged-1. These results support the prognostic value for determination of GPER expression in breast cancer.

Item Type:	Journal article
Publication Title:	Oncotarget
Creators:	Martin, S.G., Lebot, M.N., Sukkarn, B., Ball, G., Green, A.R., Rakha, E.A., Ellis, I.O. and Storr, S.J.
Publisher:	Impact Journals
Date:	2018
Volume:	9
Number:	40
ISSN:	1949-2553
Identifiers:	Number Type 10.18632/oncotarget.25408 DOI
Rights:	Copyright: Martin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	10 May 2018 10:50
Last Modified:	16 Jul 2018 13:46
URI:	https://irep.ntu.ac.uk/id/eprint/33517

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