Tools
Tools
Piasecki, M. 
ORCID: 0000-0002-7804-4631, Ireland, A., Coulson, J. ORCID: 0000-0001-9758-6295, Stashuk, D.W., Hamilton-Wright, A., Swiecicka, A., Rutter, M.K., McPhee, J.S. and Jones, D.A.,
2016.
Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling.
Physiological Reports, 4 (19): e12987.
ISSN 2051-817X
|
Text
11439_Piasecki.pdf - Published version Download (815kB) | Preview |
Abstract
Muscle motor unit numbers decrease markedly in old age, while remaining motor units are enlarged and can have reduced neuromuscular junction transmission stability. However, it is possible that regular intense physical activity throughout life can attenuate this remodeling. The aim of this study was to compare the number, size, and neuromuscular junction transmission stability of tibialis anterior (TA) motor units in healthy young and older men with those of exceptionally active master runners. The distribution of motor unit potential (MUP) size was determined from intramuscular electromyographic signals recorded in healthy male Young (mean ± SD, 26 ± 5 years), Old (71 ± 4 years) and Master Athletes (69 ± 3 years). Relative differences between groups in numbers of motor units was assessed using two methods, one comparing MUP size and muscle cross‐sectional area (CSA) determined with MRI, the other comparing surface recorded MUPs with maximal compound muscle action potentials and commonly known as a “motor unit number estimate (MUNE)”. Near fiber (NF) jiggle was measured to assess neuromuscular junction transmission stability. TA CSA did not differ between groups. MUNE values for the Old and Master Athletes were 45% and 40%, respectively, of the Young. Intramuscular MUPs of Old and Master Athletes were 43% and 56% larger than Young. NF jiggle was slightly higher in the Master Athletes, with no difference between Young and Old. These results show substantial and similar motor unit loss and remodeling in Master Athletes and Old individuals compared with Young, which suggests that lifelong training does not attenuate the age‐related loss of motor units.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Physiological Reports | ||||
| Creators: | Piasecki, M., Ireland, A., Coulson, J., Stashuk, D.W., Hamilton-Wright, A., Swiecicka, A., Rutter, M.K., McPhee, J.S. and Jones, D.A. | ||||
| Publisher: | John Wiley | ||||
| Date: | October 2016 | ||||
| Volume: | 4 | ||||
| Number: | 19 | ||||
| ISSN: | 2051-817X | ||||
| Identifiers: |
|
||||
| Rights: | © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | ||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 28 Jun 2018 10:44 | ||||
| Last Modified: | 28 Jun 2018 10:44 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/33937 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
